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<p>Designing multifunctional wound dressings with admirable mechanical virtues, appropriate electrical conductivity, and good antibacterial performance is critical for preventing infection and promoting tissue repair. Herein, a conductive gellan–agar composite film reinforced with chopped PCL–gelatin electrospun fibers containing polyaniline–graphene (PAG) and loaded with ciprofloxacin (Cip)–encapsulated PCL particles, was developed. The highest electrical conductivity (5.6 × 10<sup>–5</sup> S.cm<sup>–1</sup>) was donated to the PCL-gelatin fibers with 1.5 wt.% PAG. The conductive film revealed desirable mechanical characteristics including tensile strength (8.51 ± 0.06 MPa) and elastic modulus (5.92 ± 0.09 MPa) by addition of PCL-gelatin-1.5 wt.% PAG chopped fibers, indicating effective reinforcement of the hydrogel-based matrix. Moreover, the system enabled sustained Cip release, and the release kinetics was well described by a first-order model. The developed film demonstrated antibacterial activity against both Gram-positive and Gram-negative strains, showing inhibition zones of 9 ± 3 mm for <i>Staphylococcus aureus</i> and 16 ± 1 mm for <i>Escherichia coli</i>. In addition, the film displayed appropriate swelling and degradation behavior, supporting its suitability as a wound-contact dressing. The developed multifunctional film in this research would be a worthy asset to prevent infection and accelerate wound repair in future studies.</p> Graphical Abstract <p></p>

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A conductive antibacterial composite film containing chopped fibers and ciprofloxacin loaded PCL particles for wound dressing application

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月15日

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  • Naghmeh Nademi,
  • Pouriya Toloee,
  • Mojdeh Mohseni,
  • Mostafa Dahmardehei,
  • Azam Molafilabi,
  • Najmeh Najmoddin

摘要

Designing multifunctional wound dressings with admirable mechanical virtues, appropriate electrical conductivity, and good antibacterial performance is critical for preventing infection and promoting tissue repair. Herein, a conductive gellan–agar composite film reinforced with chopped PCL–gelatin electrospun fibers containing polyaniline–graphene (PAG) and loaded with ciprofloxacin (Cip)–encapsulated PCL particles, was developed. The highest electrical conductivity (5.6 × 10–5 S.cm–1) was donated to the PCL-gelatin fibers with 1.5 wt.% PAG. The conductive film revealed desirable mechanical characteristics including tensile strength (8.51 ± 0.06 MPa) and elastic modulus (5.92 ± 0.09 MPa) by addition of PCL-gelatin-1.5 wt.% PAG chopped fibers, indicating effective reinforcement of the hydrogel-based matrix. Moreover, the system enabled sustained Cip release, and the release kinetics was well described by a first-order model. The developed film demonstrated antibacterial activity against both Gram-positive and Gram-negative strains, showing inhibition zones of 9 ± 3 mm for Staphylococcus aureus and 16 ± 1 mm for Escherichia coli. In addition, the film displayed appropriate swelling and degradation behavior, supporting its suitability as a wound-contact dressing. The developed multifunctional film in this research would be a worthy asset to prevent infection and accelerate wound repair in future studies.

Graphical Abstract