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<p>In this study, nanoimprint lithography was employed to fabricate micropillars on the surface of a poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) film. In the next step, a hydrothermal method was used to grow zinc oxide (ZnO) nanostructures on the PVDF-HFP film. The antibacterial properties of the resulting films were evaluated against <i>Staphylococcus aureus</i> (<i>S. aureus</i>) and <i>Escherichia coli</i> (<i>E. coli</i>). The sharp ZnO nanostructures exhibited strong antibacterial activity through both physical membrane disruption and chemical interactions, including ion release and oxidative stress. The effect of micropillar structures on the antibacterial behavior of PVDF-HFP films was also investigated. The results show that the presence of micropillars enhanced the antibacterial efficacy. The increase in surface area enabled a higher concentration growth of ZnO nanostructures, which contributed to more efficient bacterial inactivation. ZnO-coated PVDF-HFP films with micropillars outperformed ZnO nanostructures grown on neat PVDF-HFP films, particularly against <i>E. coli</i>. Viability assays revealed a substantial reduction in bacterial survival, with only 3.80% of <i>S. aureus</i> and 1.36% of <i>E. coli</i> cells remaining viable on PVDF-HFP films with surface micropillars and ZnO. These findings highlight the potential of ZnO-coated, microtextured PVDF-HFP films as effective antibacterial materials for future biomedical and food packaging applications.</p><p></p>

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Effect of micropillar surface topography on the antibacterial performance of zinc oxide coated polymer films

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月13日

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  • Quang Hung Nguyen,
  • Tien Thanh Nguyen,
  • Vi Khanh Truong,
  • Avinash Baji

摘要

In this study, nanoimprint lithography was employed to fabricate micropillars on the surface of a poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) film. In the next step, a hydrothermal method was used to grow zinc oxide (ZnO) nanostructures on the PVDF-HFP film. The antibacterial properties of the resulting films were evaluated against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). The sharp ZnO nanostructures exhibited strong antibacterial activity through both physical membrane disruption and chemical interactions, including ion release and oxidative stress. The effect of micropillar structures on the antibacterial behavior of PVDF-HFP films was also investigated. The results show that the presence of micropillars enhanced the antibacterial efficacy. The increase in surface area enabled a higher concentration growth of ZnO nanostructures, which contributed to more efficient bacterial inactivation. ZnO-coated PVDF-HFP films with micropillars outperformed ZnO nanostructures grown on neat PVDF-HFP films, particularly against E. coli. Viability assays revealed a substantial reduction in bacterial survival, with only 3.80% of S. aureus and 1.36% of E. coli cells remaining viable on PVDF-HFP films with surface micropillars and ZnO. These findings highlight the potential of ZnO-coated, microtextured PVDF-HFP films as effective antibacterial materials for future biomedical and food packaging applications.