Scholarlink

<p>The process of catabolism recovers the chemical waste product known as creatinine from creatine. The measurement of creatinine in human blood and urine samples is crucial since the body’s renal, muscular, thyroid, and kidney functions are directly impacted by this proteins amount. The amount of creatinine in human blood and urine samples facilitates the monitoring and diagnosis of health problems. Several techniques are used, including chemiluminescence, chromatography, HPLC, and others, but they are all expensive for the patient. The electrode-based sensing detection approach is the most economical and efficient way to measure the creatinine level. The substance deposited on the electrode surfaces serves as the foundation for the electrode-based sensor. Multiwalled carbon nanotubes (MWCNTs) are a class of nano- and microstructure materials that are widely used in chemical and biological applications due to their exceptional physical and chemical properties. A few research have been conducted to determine the sensing efficiency against creatinine (CR), a crucial biomolecule found in the human body, across a wide range of applications. The multiwalled carbon nanotubes (FMWCNTs) used in this study were functionalized initially,&#xa0;and their morphological and chemical characteristics were investigated in order to preserve this viewpoint. The chemical functional characteristics were investigated using FTIR spectroscopy, and the findings show the carboxylic (-COOH) bonding. The SEM and TEM were used for the morphological observations, while X-ray photoelectron spectroscopy (XPS) and Brunauer–Emmett–Teller (BET) were employed for to know their surface studies. The glassy carbon electrode (GCE) was coated with layers of FMWCNTs to measure the creatinine levels in PBS. For the FMWCNTs/GCE electrode-based examination, a variety of parameters were measured, such as the influence of analyte concentrations, scan rates, cyclic test, Chronoamperometry (CrA), and electrochemical impedance spectroscopy. To assess the efficacy of FMWCNTs/GCE-based sensor, a wide range of creatinine concentrations (CR− 0.98 to 500&#xa0;µM in PBS) were employed. Also, the scan rates of FMWCNTs/ GCE-based sensor were selected and analyzed, ranging from very low to high (0.005 to 0.15&#xa0;V/s). The cyclic response test was used to assess the FMWCNTs/GCE sensors persistence, and it was monitored every other third day for up to one month. The measurement range for the chronoamperometric (CA) responses were in the range from 0 to 1000<i>&#xa0;s</i>. For the same range of concentrations, the electrochemical impedance (EI) was also measured as well and a circuit was designed and explained using the results.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Detection of creatinine via fast electrode-based nanosensor templated by functional carbon nanotubes

  • 期刊论文

  • 发表日期：

    2026年7月12日

查看全文
  • Rizwan Wahab,
  • Manawwer Alam

摘要

The process of catabolism recovers the chemical waste product known as creatinine from creatine. The measurement of creatinine in human blood and urine samples is crucial since the body’s renal, muscular, thyroid, and kidney functions are directly impacted by this proteins amount. The amount of creatinine in human blood and urine samples facilitates the monitoring and diagnosis of health problems. Several techniques are used, including chemiluminescence, chromatography, HPLC, and others, but they are all expensive for the patient. The electrode-based sensing detection approach is the most economical and efficient way to measure the creatinine level. The substance deposited on the electrode surfaces serves as the foundation for the electrode-based sensor. Multiwalled carbon nanotubes (MWCNTs) are a class of nano- and microstructure materials that are widely used in chemical and biological applications due to their exceptional physical and chemical properties. A few research have been conducted to determine the sensing efficiency against creatinine (CR), a crucial biomolecule found in the human body, across a wide range of applications. The multiwalled carbon nanotubes (FMWCNTs) used in this study were functionalized initially, and their morphological and chemical characteristics were investigated in order to preserve this viewpoint. The chemical functional characteristics were investigated using FTIR spectroscopy, and the findings show the carboxylic (-COOH) bonding. The SEM and TEM were used for the morphological observations, while X-ray photoelectron spectroscopy (XPS) and Brunauer–Emmett–Teller (BET) were employed for to know their surface studies. The glassy carbon electrode (GCE) was coated with layers of FMWCNTs to measure the creatinine levels in PBS. For the FMWCNTs/GCE electrode-based examination, a variety of parameters were measured, such as the influence of analyte concentrations, scan rates, cyclic test, Chronoamperometry (CrA), and electrochemical impedance spectroscopy. To assess the efficacy of FMWCNTs/GCE-based sensor, a wide range of creatinine concentrations (CR− 0.98 to 500 µM in PBS) were employed. Also, the scan rates of FMWCNTs/ GCE-based sensor were selected and analyzed, ranging from very low to high (0.005 to 0.15 V/s). The cyclic response test was used to assess the FMWCNTs/GCE sensors persistence, and it was monitored every other third day for up to one month. The measurement range for the chronoamperometric (CA) responses were in the range from 0 to 1000 s. For the same range of concentrations, the electrochemical impedance (EI) was also measured as well and a circuit was designed and explained using the results.