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<p>In this study, a non-enzymatic glucose sensor based on a ZnO:CuO composite nanostructure was developed. The composite was synthesized via a hydrothermal method and subsequently deposited onto the surface of a carbon electrode. Structural and morphological properties of the synthesized materials were characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction (XRD), confirming the successful formation of the ZnO:CuO heterostructure. The results indicate that the morphology of the ZnO:CuO nanostructures varied depending on the relative ratios of ZnO and CuO, with the 2:1 ratio demonstrating the most favorable structural and electrochemical characteristics. Glucose detection and quantification were performed using cyclic voltammetry (CV) electrochemical impedance spectroscopy (EIS) and amperometric measurements. The proposed sensor exhibited a high sensitivity of 520 µA mM<sup>−1</sup>&#xa0;cm<sup>−2</sup>, a low limit of detection (LOD) of 0.446&#xa0;µM and a wide linear range of 0–10&#xa0;mM, indicating excellent analytical capability in alkaline media. In addition, the sensor demonstrated good selectivity against common interfering substances, such as sodium chloride, urea, dopamine and ascorbic acid. These findings highlight the potential of ZnO:CuO-based electrochemical sensors for the development of high-sensitivity, non-enzymatic glucose monitoring systems, particularly in applications related to diabetes management.</p>

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Development of a non-enzymatic glucose sensor based on ZnO:CuO composite nanostructure

  • 期刊论文

  • 发表日期：

    2026年6月24日

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  • Chi Tran Nhu,
  • Vuong Nguyen Danh,
  • Phu Nguyen Dang

摘要

In this study, a non-enzymatic glucose sensor based on a ZnO:CuO composite nanostructure was developed. The composite was synthesized via a hydrothermal method and subsequently deposited onto the surface of a carbon electrode. Structural and morphological properties of the synthesized materials were characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction (XRD), confirming the successful formation of the ZnO:CuO heterostructure. The results indicate that the morphology of the ZnO:CuO nanostructures varied depending on the relative ratios of ZnO and CuO, with the 2:1 ratio demonstrating the most favorable structural and electrochemical characteristics. Glucose detection and quantification were performed using cyclic voltammetry (CV) electrochemical impedance spectroscopy (EIS) and amperometric measurements. The proposed sensor exhibited a high sensitivity of 520 µA mM−1 cm−2, a low limit of detection (LOD) of 0.446 µM and a wide linear range of 0–10 mM, indicating excellent analytical capability in alkaline media. In addition, the sensor demonstrated good selectivity against common interfering substances, such as sodium chloride, urea, dopamine and ascorbic acid. These findings highlight the potential of ZnO:CuO-based electrochemical sensors for the development of high-sensitivity, non-enzymatic glucose monitoring systems, particularly in applications related to diabetes management.