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<p>The voltammetric detection of azithromycin (AM) based on carbon nanotube chitosan composite material polymerized using methionine (PMT-CS/CNTE) has been reported in the present work. Various parameters affecting the efficiency of the developed sensor were studied by the application of cyclic voltammetry&#xa0;(CV), linear sweep voltammetry (LSV), scanning electron microscopy (SEM), and electrochemical impedance spectroscopy (EIS). The diffusion-controlled electrochemical oxidation of AM was observed in the entire pH range (5.5–8.0) with an optimum response at 6.5 pH of 0.2&#xa0;M phosphate buffer solution (PBS). The scan rate variation studies revealed the oxidation of AM involves the transfer of one proton and one electron. The fabricated PMT-CS/CNTE showed a wide linear range of 2.0 to 80.0&#xa0;μM for both CV and LSV with detection limits (DL) of 0.621&#xa0;μM and 0.335&#xa0;μM, respectively. The selectivity of the developed sensor remained unaltered even in the presence of the interferents like metal ions and other organic molecules. The proposed sensor for the detection of AM depicted excellent repeatability, stability, and reproducibility. Pharmaceutical sample analysis by the designed sensor gave a good recovery rate and can be authenticated as the reliable sensor for AM detection in real samples.</p>

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Azithromycin biosensing using methionine-modified chitosan composite electrode

  • 期刊论文

  • 发表日期：

    2026年1月6日

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  • K. P. Moulya,
  • J. G. Manjunatha,
  • T. Girish

摘要

The voltammetric detection of azithromycin (AM) based on carbon nanotube chitosan composite material polymerized using methionine (PMT-CS/CNTE) has been reported in the present work. Various parameters affecting the efficiency of the developed sensor were studied by the application of cyclic voltammetry (CV), linear sweep voltammetry (LSV), scanning electron microscopy (SEM), and electrochemical impedance spectroscopy (EIS). The diffusion-controlled electrochemical oxidation of AM was observed in the entire pH range (5.5–8.0) with an optimum response at 6.5 pH of 0.2 M phosphate buffer solution (PBS). The scan rate variation studies revealed the oxidation of AM involves the transfer of one proton and one electron. The fabricated PMT-CS/CNTE showed a wide linear range of 2.0 to 80.0 μM for both CV and LSV with detection limits (DL) of 0.621 μM and 0.335 μM, respectively. The selectivity of the developed sensor remained unaltered even in the presence of the interferents like metal ions and other organic molecules. The proposed sensor for the detection of AM depicted excellent repeatability, stability, and reproducibility. Pharmaceutical sample analysis by the designed sensor gave a good recovery rate and can be authenticated as the reliable sensor for AM detection in real samples.