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<p>A novel field-effect transistor was fabricated from a single β-cyclodextrin-functionalized graphene nanoribbon for lab-on-chip biosensor applications. The synthetic recipe started with the graphene nanoribbon synthesis via the unzipping of MWCNT. The graphene nanoribbons were reduced by hydrazine in the presence of β-cyclodextrin to obtain β-cyclodextrin functionalized graphene nanoribbons, which were confirmed by transmission electron microscopy (TEM), selected-area electron diffraction (SAED), Raman spectroscopy, FTIR, and X-ray photoelectron spectroscopy (XPS). The 1-admantene-ChEt-ChOx bienzymes are immobilized in the β-cyclodextrin functionalized graphene nanoribbons for the selective detection of cholesterol. A field effect transistor was fabricated by depositing 1-admantene-ChEt-ChOx bienzymes immobilized β-cyclodextrin functionalized graphene nanoribbons on a Si/SiO<sub>2</sub> chip coated with Ti/Au nano-comb electrode. The constructed β-CD-GR-FET showed a fast and linear response against cholesterol concentration along a wide range from 0.01&#xa0;mM to 25&#xa0;mM with a sensitivity of 81.5 μA/mM.cm<sup>2</sup>. It also shows high selectivity, reliability, and reproducibility. This novel β-CD-GR-FET will open a new avenue to easily estimate the precise amount of cholesterol in the biological fluids with remarkable sensitivity.</p>

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Development of a field-effect transistor based on 1-admantene-ChEt-ChOx bienzymes immobilized in the β-cyclodextrin functionalized graphene nanoribbons for accurate and fast detection of cholesterol

  • 期刊论文

  • 发表日期：

    2025年8月25日

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  • Waleed E. Mahmoud,
  • G. H. Al-Harbi,
  • Amira R. Abdullah

摘要

A novel field-effect transistor was fabricated from a single β-cyclodextrin-functionalized graphene nanoribbon for lab-on-chip biosensor applications. The synthetic recipe started with the graphene nanoribbon synthesis via the unzipping of MWCNT. The graphene nanoribbons were reduced by hydrazine in the presence of β-cyclodextrin to obtain β-cyclodextrin functionalized graphene nanoribbons, which were confirmed by transmission electron microscopy (TEM), selected-area electron diffraction (SAED), Raman spectroscopy, FTIR, and X-ray photoelectron spectroscopy (XPS). The 1-admantene-ChEt-ChOx bienzymes are immobilized in the β-cyclodextrin functionalized graphene nanoribbons for the selective detection of cholesterol. A field effect transistor was fabricated by depositing 1-admantene-ChEt-ChOx bienzymes immobilized β-cyclodextrin functionalized graphene nanoribbons on a Si/SiO2 chip coated with Ti/Au nano-comb electrode. The constructed β-CD-GR-FET showed a fast and linear response against cholesterol concentration along a wide range from 0.01 mM to 25 mM with a sensitivity of 81.5 μA/mM.cm2. It also shows high selectivity, reliability, and reproducibility. This novel β-CD-GR-FET will open a new avenue to easily estimate the precise amount of cholesterol in the biological fluids with remarkable sensitivity.