<p>The recent advancements in wearable flexible piezoelectric sensors and their real-time applications are explored in this article. It highlights the materials used, fabrication methods, piezoelectric coefficients, maximum output voltages, sensitivity, mechanical flexibility, and self-powered applications. The article covers a range of materials, including inorganic piezoelectric materials, organic piezoelectric polymers, and composite materials, based on piezoelectric ceramic/polymer and piezoelectric ceramic/piezoelectric polymer composites. The development of these materials into flexible sensors makes them suitable for health monitoring, human motion detection and activity tracking, energy harvesting, robotics and artificial intelligence interfaces, and environmental and structural monitoring. The integration of these sensors into wearable devices, such as smartwatches, fitness trackers, health monitoring patches, smart textiles, and e-skins, emphasizes their potential for self-powered, lightweight, and portable applications. These sensors collect data continuously without interfering with the wearer’s routine activities. This not only improves patient comfort but also reduces healthcare burdens by minimizing the need for hospital visits, enabling telehealth, and supporting early intervention strategies.</p> Graphical Abstract <p></p>