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<p>Burn injuries demand advanced therapies that control infection, regulate inflammation, and accelerate tissue repair. This study reports biopolymer-based hydrogels reinforced with natural zeolite (clinoptilolite) (NZ) and zinc oxide (ZnO) nanoparticles for multifunctional burn wound treatment. Structural analyses (FTIR, XRD, SEM, EDX) confirmed successful NZ-ZnO integration within the gel network. The optimized formulation (LG2) exhibited strong antibacterial activity with inhibition zones up to 3.20 ± 0.05&#xa0;mm against <i>S. aureus</i> and 3.06 ± 0.06&#xa0;mm against <i>E. coli</i>. Hemolysis remained &lt; 5% at 1&#xa0;mg/mL, and skin irritation was mild and reversible. In vivo, LG2 achieved ~ 81% wound closure by day 14, compared with ~ 33% in untreated controls and ~ 42% in blank gels. Histology revealed dense collagen deposition and near-complete re-epithelialization. Antioxidant analyses showed elevated SOD (0.095&#xa0;IU/µL), CAT (0.91&#xa0;IU/µL), and GSH (0.93&#xa0;µmol/mg), with reduced MDA (63.45&#xa0;mg/mL). ELISA confirmed significant cytokine downregulation, reducing TNF-α from 361.8 to 65.26&#xa0;pg/mL and IL-6 from 32.17 to 5.42&#xa0;ng/L. These results demonstrate that NZ-ZnO-loaded hydrogels combine antimicrobial, anti-inflammatory, and antioxidant properties to accelerate burn wound healing, offering a safe and effective platform for next-generation bioactive dressings.</p> Graphical abstract <p></p>

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Synergistic zeolite polymer/ZnO nanocomposite gels: in vivo healing, and biocompatibility in burn wound treatment

  • 期刊论文

  • 发表日期：

    2026年4月17日

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  • Muhammad Shahjahan,
  • Yasir Iqbal,
  • Khuram Shahzad,
  • Abdullah K. Alanazi,
  • Shahzad Ali Shahid Chatha,
  • Ikram Ullah Khan,
  • Sami Ullah,
  • Haiyan Cao

摘要

Burn injuries demand advanced therapies that control infection, regulate inflammation, and accelerate tissue repair. This study reports biopolymer-based hydrogels reinforced with natural zeolite (clinoptilolite) (NZ) and zinc oxide (ZnO) nanoparticles for multifunctional burn wound treatment. Structural analyses (FTIR, XRD, SEM, EDX) confirmed successful NZ-ZnO integration within the gel network. The optimized formulation (LG2) exhibited strong antibacterial activity with inhibition zones up to 3.20 ± 0.05 mm against S. aureus and 3.06 ± 0.06 mm against E. coli. Hemolysis remained < 5% at 1 mg/mL, and skin irritation was mild and reversible. In vivo, LG2 achieved ~ 81% wound closure by day 14, compared with ~ 33% in untreated controls and ~ 42% in blank gels. Histology revealed dense collagen deposition and near-complete re-epithelialization. Antioxidant analyses showed elevated SOD (0.095 IU/µL), CAT (0.91 IU/µL), and GSH (0.93 µmol/mg), with reduced MDA (63.45 mg/mL). ELISA confirmed significant cytokine downregulation, reducing TNF-α from 361.8 to 65.26 pg/mL and IL-6 from 32.17 to 5.42 ng/L. These results demonstrate that NZ-ZnO-loaded hydrogels combine antimicrobial, anti-inflammatory, and antioxidant properties to accelerate burn wound healing, offering a safe and effective platform for next-generation bioactive dressings.

Graphical abstract