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<p>Although traditional cancer therapy is widely used, it still faces treatment and some serious adverse reactions. This study developed an “all-in-one” multifunctional nanotherapeutic agent that integrates the dual capabilities of magnetic resonance imaging (MRI) and photothermal/chemodynamic therapy (PPT/CDT). In brief, a multifunctional nanotherapeutic agent was successfully synthesized for MRI and photothermal/chemodynamic therapy by modifying a manganese gallate complex with dopamine (Mn-GA@PDA NPs). We found that at a concentration of 400&#xa0;μg/mL of Mn-GA@PDA NPs and under irradiation with near-infrared light at 1.5&#xa0;W/cm<sup>2</sup> for 10&#xa0;min, the temperature could rapidly rise to 59&#xa0;℃. Moreover, the cell survival rate was much lower than that of the group without laser irradiation. In the animal experiment, a significant difference between the Mn-GA@PDA NPs + NIR group and the PBS group. The antitumor effect was 9.5 times that of the PBS group. The in vitro and in vivo experiments demonstrated that the Mn-GA@PDA NPs, possessing chemodynamic and photothermal activity, inhibited the growth of breast cancer 4T1 cells. Due to the inherent high paramagnetism of manganese ion, the Mn-GA@PDA NPs effectively accelerate the longitudinal relaxation rate under normal physiological conditions, demonstrating certain T1-weighted magnetic resonance imaging ability. The calculated molar longitudinal relaxation rate was r<sub>1</sub> = 4.4&#xa0;mM<sup>−1</sup>&#xa0;s<sup>−1</sup>, providing robust support for precision medicine. Our Mn-chelating nanoplatform is a promising MRI–visible theragnostic agent for synergistic cancer combination therapy.</p>

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Dopamine-loaded manganese gallate diagnostic nanoplatform for MRI-guided synergistic photothermal and chemodynamic cancer therapy

  • 期刊论文

  • 发表日期：

    2026年4月7日

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  • Yating Liu,
  • Jie Zeng,
  • Xianghua Yang,
  • Ziyan Chen,
  • Wang Sun,
  • Shuo Tan,
  • Feng Chen,
  • Zhenghuan Zhao,
  • Xinyu Zhao

摘要

Although traditional cancer therapy is widely used, it still faces treatment and some serious adverse reactions. This study developed an “all-in-one” multifunctional nanotherapeutic agent that integrates the dual capabilities of magnetic resonance imaging (MRI) and photothermal/chemodynamic therapy (PPT/CDT). In brief, a multifunctional nanotherapeutic agent was successfully synthesized for MRI and photothermal/chemodynamic therapy by modifying a manganese gallate complex with dopamine (Mn-GA@PDA NPs). We found that at a concentration of 400 μg/mL of Mn-GA@PDA NPs and under irradiation with near-infrared light at 1.5 W/cm2 for 10 min, the temperature could rapidly rise to 59 ℃. Moreover, the cell survival rate was much lower than that of the group without laser irradiation. In the animal experiment, a significant difference between the Mn-GA@PDA NPs + NIR group and the PBS group. The antitumor effect was 9.5 times that of the PBS group. The in vitro and in vivo experiments demonstrated that the Mn-GA@PDA NPs, possessing chemodynamic and photothermal activity, inhibited the growth of breast cancer 4T1 cells. Due to the inherent high paramagnetism of manganese ion, the Mn-GA@PDA NPs effectively accelerate the longitudinal relaxation rate under normal physiological conditions, demonstrating certain T1-weighted magnetic resonance imaging ability. The calculated molar longitudinal relaxation rate was r1 = 4.4 mM−1 s−1, providing robust support for precision medicine. Our Mn-chelating nanoplatform is a promising MRI–visible theragnostic agent for synergistic cancer combination therapy.