<p>Implant-related infections are a significant and urgent problem in clinical medicine, which need to be addressed for a long time. Here, we designed a new type of low-cost, low elastic modulus, non-toxic, and easily manufacturable Ti–Zr–Nb–Mo series biomedical <i>β</i>-Ti alloy through machine learning methods and introduced Cu elements to impart antibacterial functionality to the alloy. The Ti_{54−<i>x</i>}Zr₁₅Nb₁₄Mo₁₇Cu_<i>x</i> (<i>x</i> = 1, 3, 5, 7 at.%) alloys achieved excellent mechanical properties with an ultra-low modulus. Moreover, the Ti_{54−<i>x</i>}Zr₁₅Nb₁₄Mo₁₇Cu_<i>x</i> alloys can inhibit both <i>Staphylococcus aureus</i> (Gram-positive bacteria) and <i>Escherichia coli</i> (Gram-negative bacteria). The potent antibacterial effect originates from the disruption of the bacterial cell wall structure induced by the reactive oxygen species (ROS). In addition, the Ti_{54−<i>x</i>}Zr₁₅Nb₁₄Mo₁₇Cu_<i>x</i> alloys also exhibit excellent biocompatibility performance, which is beneficial for the clinical application. This work suggests that Ti_{54−<i>x</i>}Zr₁₅Nb₁₄Mo₁₇Cu_<i>x</i> alloy implants have potential practicality in treating orthopedic infections.</p> Graphical Abstract <p></p>