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<p>This study presents a novel and safer method for fabricating electrospun nanofibers from polyvinyl alcohol (PVA) and high-molecular-weight poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV, Mw&#xa0;≈&#xa0;2.3 million g/mol) using a dimethyl sulfoxide (DMSO)–water co-solvent system. Electrospinning of high-molecular-weight PHBV using safer solvents remains challenging due to its limited solubility. To our knowledge, this is the first successful use of DMSO to dissolve PHBV for electrospinning. Compared to conventional toxic solvents like hexafluoro-2-propanol and chloroform, the DMSO–water system is a safer and less toxic alternative. The miscibility, morphology, thermal behavior, wettability, water absorption, mechanical strength, and biodegradability of the electrospun PVA/PHBV-blend nanofibers were systematically investigated. FTIR analysis revealed the formation of intermolecular hydrogen bonding, which enhances polymer compatibility by disrupting crystallinity and promoting miscibility at the molecular level. Optimized solvent ratios and electrospinning parameters yielded uniform fibers with enhanced mechanical performance. A freeze–thaw crosslinking technique significantly increased the tensile modulus from 35 to 83&#xa0;MPa, improved hydrophilicity, and enabled controlled in vitro degradation. Blending PHBV with PVA reduced brittleness and markedly improved ductility (elongation at break increased by approx. 110%), and the water contact angle decreased from 110° to 48.6°, indicating improved wettability. The proposed approach offers a safer and more environmentally acceptable route for producing high-performance PHBV-based nanofibers for potential biomedical and cosmetic applications.</p> Graphical abstract <p></p>

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Electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/poly(vinyl alcohol) nanofibers prepared via a DMSO–water co-solvent and freeze–thaw crosslinking

  • 期刊论文

  • 发表日期：

    2025年11月23日

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  • Ehsan Niknejad,
  • Reza Jafari,
  • Gelareh Momen

摘要

This study presents a novel and safer method for fabricating electrospun nanofibers from polyvinyl alcohol (PVA) and high-molecular-weight poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV, Mw ≈ 2.3 million g/mol) using a dimethyl sulfoxide (DMSO)–water co-solvent system. Electrospinning of high-molecular-weight PHBV using safer solvents remains challenging due to its limited solubility. To our knowledge, this is the first successful use of DMSO to dissolve PHBV for electrospinning. Compared to conventional toxic solvents like hexafluoro-2-propanol and chloroform, the DMSO–water system is a safer and less toxic alternative. The miscibility, morphology, thermal behavior, wettability, water absorption, mechanical strength, and biodegradability of the electrospun PVA/PHBV-blend nanofibers were systematically investigated. FTIR analysis revealed the formation of intermolecular hydrogen bonding, which enhances polymer compatibility by disrupting crystallinity and promoting miscibility at the molecular level. Optimized solvent ratios and electrospinning parameters yielded uniform fibers with enhanced mechanical performance. A freeze–thaw crosslinking technique significantly increased the tensile modulus from 35 to 83 MPa, improved hydrophilicity, and enabled controlled in vitro degradation. Blending PHBV with PVA reduced brittleness and markedly improved ductility (elongation at break increased by approx. 110%), and the water contact angle decreased from 110° to 48.6°, indicating improved wettability. The proposed approach offers a safer and more environmentally acceptable route for producing high-performance PHBV-based nanofibers for potential biomedical and cosmetic applications.

Graphical abstract