Scholarlink

<p>Locally induced photodynamic therapy (PDT) with internally generated light could offer opportunities for the efficient treatment of deep tissue tumors and bacteria hidden in places where external light cannot reach. To achieve this, luminol acrylamide was synthesized and used to prepare nanospheres that were loaded with a polyurethane photosensitizer and the enzyme horseradish peroxidase. With H<sub>2</sub>O<sub>2</sub> the nanoparticles were self-illuminating and showed good antibacterial abilities and also anticancer effects via a PDT mechanism indicating efficient self-luminous functionality. The self-luminating nanospheres could potentially be used in sterilization and for cancer depression.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Design and in vitro photodynamic evaluation of self-illuminating nanospheres loaded with polyurethane containing protoporphyrin IX for anticancer and antibacterial applications

  • 期刊论文

  • 发表日期：

    2025年9月9日

查看全文
  • Zhengnan Lu,
  • Yi Wang,
  • Peng Zhang,
  • Yang Sheng,
  • Yixin Sun,
  • Mark Bradley,
  • Rong Zhang

摘要

Locally induced photodynamic therapy (PDT) with internally generated light could offer opportunities for the efficient treatment of deep tissue tumors and bacteria hidden in places where external light cannot reach. To achieve this, luminol acrylamide was synthesized and used to prepare nanospheres that were loaded with a polyurethane photosensitizer and the enzyme horseradish peroxidase. With H2O2 the nanoparticles were self-illuminating and showed good antibacterial abilities and also anticancer effects via a PDT mechanism indicating efficient self-luminous functionality. The self-luminating nanospheres could potentially be used in sterilization and for cancer depression.