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<p>Zinc-modified hydroxyapatite (ZnₓHA) is a promising biomaterial for bone implants due to its osteoconductivity and antimicrobial properties. This work explores the functionalization of porous zinc-substituted hydroxyapatite (Zn₀.₅HA), synthesized via a wet precipitation method, with cucurbit[n]nurils (CB[n], <i>n</i> = 6, 7, 8) to develop composite materials. The composites were characterized by FTIR spectroscopy and scanning electron microscopy (SEM), revealing distinct surface morphologies dependent on the CB[n] type. All composites exhibited high hemocompatibility (hemolysis &lt; 5%). However, functionalization with CB[n] led to a statistically significant decrease in antibacterial activity against Escherichia coli compared to unmodified Zn₀.₅HA. This reduction correlates with the macrocycle cavity size and is attributed to the complexation of Zn²⁺ ions, which likely modulates their release. A comparative analysis of the properties of all composite types is presented. The results demonstrate the feasibility of creating biocompatible Zn₀.₅HA-CB[n] platforms, highlighting the interplay between surface modification and functional performance.</p>

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Zn-Modified composite materials based on hydroxyapatite and Cucurbit[n]urils

  • 期刊论文

  • 发表日期：

    2026年3月17日

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  • A.E. Ukhov,
  • D.A. Fedorishin,
  • D.S. Zaitsev,
  • N.M. Korotchenko,
  • A.A. Bakibaev

摘要

Zinc-modified hydroxyapatite (ZnₓHA) is a promising biomaterial for bone implants due to its osteoconductivity and antimicrobial properties. This work explores the functionalization of porous zinc-substituted hydroxyapatite (Zn₀.₅HA), synthesized via a wet precipitation method, with cucurbit[n]nurils (CB[n], n = 6, 7, 8) to develop composite materials. The composites were characterized by FTIR spectroscopy and scanning electron microscopy (SEM), revealing distinct surface morphologies dependent on the CB[n] type. All composites exhibited high hemocompatibility (hemolysis < 5%). However, functionalization with CB[n] led to a statistically significant decrease in antibacterial activity against Escherichia coli compared to unmodified Zn₀.₅HA. This reduction correlates with the macrocycle cavity size and is attributed to the complexation of Zn²⁺ ions, which likely modulates their release. A comparative analysis of the properties of all composite types is presented. The results demonstrate the feasibility of creating biocompatible Zn₀.₅HA-CB[n] platforms, highlighting the interplay between surface modification and functional performance.