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Background <p>Esophageal injury following radiofrequency ablation for atrial fibrillation is closely associated with esophageal temperature. Studies suggest that discontinuous ablation may prevent excessive esophageal temperature rise; however, the temperature characteristics of discontinuous ablation strategy during ultra-high-power short-duration ablation remain unexplored.</p> Methods <p>Fresh porcine cardiac tissue was used. A 15-mm deep vertical hole was drilled from the endocardial surface, and a temperature probe was inserted. The QDOT catheter (Biosense Webster) was positioned at the endocardial site of probe insertion, and the lesion was created using a 90 W, 4-s ablation strategy. After a predefined interval, a second lesion was created.Based on the inter-lesion time interval, samples were divided into four groups: 10&#xa0;s (group 1), 20&#xa0;s (group 2), 40&#xa0;s (group 3), and 60&#xa0;s (group 4). Temperature was recorded every 10&#xa0;s.</p> Results <p>Temperature curves in groups 1 and 2 exhibited a unimodal pattern, whereas groups 3 and 4 showed a bimodal pattern. Mean peak temperatures differed among groups: group 1, 39.1&#xa0;°C (38.6–39.5&#xa0;°C); group 2, 38.4&#xa0;°C (38.0–38.7&#xa0;°C); group 3, peak 38.0&#xa0;°C (37.5–38.2&#xa0;°C) with a sub-peak of 37.3&#xa0;°C (37.1–37.5&#xa0;°C); group 4, peak 37.8&#xa0;°C (37.5–38.0&#xa0;°C) with a sub-peak of 37.3&#xa0;°C (36.9–37.6&#xa0;°C). Peak temperatures differed significantly among groups (P &lt; 0.0001). Analysis of repeated temperature measurements revealed a statistically significant between-groups effect (F = 7.2, P &lt; 0.002). Using &lt; 38.5&#xa0;°C as a safety threshold for peak temperature, 8 cases (73.3%) in group 1 exceeded the threshold, 4 cases (27%) in group 2 reached the threshold, whereas neither group 3 nor group 4 exceeded it.</p> Conclusion <p>Tissue temperature demonstrates significant delayed and cumulative effects during ultra-high-power short-duration ablation. In our ex vivo model, longer inter-lesion intervals were associated with a more gradual temperature rise.</p>

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Correlation between tissue temperature and ablation interval time under ultra-high-power short-duration ablation: Ex vivo porcine model

  • 期刊论文

  • 发表日期：

    2026年6月18日

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  • Hanxiong Liu,
  • Jialing He,
  • Jinchen He,
  • Shuxing Wu,
  • Xianchen Yang,
  • Guoshu Yang,
  • Duan Luo,
  • Yongxin Yang,
  • Bao Xu,
  • Guijun He,
  • Zhen Zhang,
  • Wei Huang

摘要

Background

Esophageal injury following radiofrequency ablation for atrial fibrillation is closely associated with esophageal temperature. Studies suggest that discontinuous ablation may prevent excessive esophageal temperature rise; however, the temperature characteristics of discontinuous ablation strategy during ultra-high-power short-duration ablation remain unexplored.

Methods

Fresh porcine cardiac tissue was used. A 15-mm deep vertical hole was drilled from the endocardial surface, and a temperature probe was inserted. The QDOT catheter (Biosense Webster) was positioned at the endocardial site of probe insertion, and the lesion was created using a 90 W, 4-s ablation strategy. After a predefined interval, a second lesion was created.Based on the inter-lesion time interval, samples were divided into four groups: 10 s (group 1), 20 s (group 2), 40 s (group 3), and 60 s (group 4). Temperature was recorded every 10 s.

Results

Temperature curves in groups 1 and 2 exhibited a unimodal pattern, whereas groups 3 and 4 showed a bimodal pattern. Mean peak temperatures differed among groups: group 1, 39.1 °C (38.6–39.5 °C); group 2, 38.4 °C (38.0–38.7 °C); group 3, peak 38.0 °C (37.5–38.2 °C) with a sub-peak of 37.3 °C (37.1–37.5 °C); group 4, peak 37.8 °C (37.5–38.0 °C) with a sub-peak of 37.3 °C (36.9–37.6 °C). Peak temperatures differed significantly among groups (P < 0.0001). Analysis of repeated temperature measurements revealed a statistically significant between-groups effect (F = 7.2, P < 0.002). Using < 38.5 °C as a safety threshold for peak temperature, 8 cases (73.3%) in group 1 exceeded the threshold, 4 cases (27%) in group 2 reached the threshold, whereas neither group 3 nor group 4 exceeded it.

Conclusion

Tissue temperature demonstrates significant delayed and cumulative effects during ultra-high-power short-duration ablation. In our ex vivo model, longer inter-lesion intervals were associated with a more gradual temperature rise.