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<p>Large animal surgeries are the standard for validating pre-clinical electrophysiology studies, and serve as an important step for the rationale underlying clinical trials. Although electrophysiologists receive extensive training in catheter-based approaches, few medical centers have the capability to perform experimental animal surgeries in large animals. Here, we present a step-by-step guide to performing an epicardial approach to pacing and sensing in a large animal sheep model, with the goal of enabling a wide variety of pacing and ablation options.</p>

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A surgical epicardial approach to mapping and ablation in large animal models

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月21日

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  • Ken S. Lizama,
  • Abdelmotogaly Elgalad,
  • Tirth A. Patel,
  • Matthews John,
  • Mehdi Razavi,
  • Mark D. McCauley

摘要

Large animal surgeries are the standard for validating pre-clinical electrophysiology studies, and serve as an important step for the rationale underlying clinical trials. Although electrophysiologists receive extensive training in catheter-based approaches, few medical centers have the capability to perform experimental animal surgeries in large animals. Here, we present a step-by-step guide to performing an epicardial approach to pacing and sensing in a large animal sheep model, with the goal of enabling a wide variety of pacing and ablation options.