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Background <p>Congestive heart failure (CHF) complicated by ventricular arrhythmias (VA) continues to account for substantial mortality. Nevertheless, national-level longitudinal evidence on mortality trends remains limited. This study investigates these patterns among U.S. adults aged ≥ 25 years across years 1999–2024.</p> Methods <p>An observational analysis of U.S. mortalities due to VA with CHF (ICD-10 I47.2, I49.0 and I50.0 respectively), was conducted using CDC WONDER. Age-adjusted mortality rates (AAMRs) per 100,000 were calculated, and temporal trends were evaluated using annual percent change (APC) and average annual percent change (AAPC), stratified by year, age, sex, race, and geographic region.</p> Results <p>Between 1999 and 2024, 60,968 deaths were accounted for VA with CHF. Overall, AAMR declined from 1.8 in 1999 to 0.9 in 2024 (AAPC: − 2.36%; <i>p</i> &lt; 0.001). A sharp decline occurred from 1999 to 2008 (APC: − 8.07; <i>p</i> &lt; 0.001), followed by a significant increase afterwards (APC: 1.01; <i>p</i> = 0.0036). AAMRs were higher in men than women (1.7 vs. 0.6). Older adults showed greatest AAMRs (4.5) compared with middle-aged (0.5) and younger adults (0.1). By race, Non-Hispanic (NH) Blacks exhibited the highest mortality rates (1.4), followed by Whites (1.1), Hispanics (0.7), and NH Others (0.6). Geographically, West Virginia recorded the highest AAMR (1.8) versus New York (0.7). The West, Midwest, and South shared similar rates (1.1), whereas the Northeast was lowest (0.8). Rural populations demonstrated higher AAMRs than urban (1.2 vs. 1.0).</p> Conclusion <p>Although VA-CHF mortality has decreased over the past two decades, disparities by race, sex, age, and geography persist, underscoring the need for targeted healthcare strategies.</p>

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Understanding the mortality trends in patients with ventricular arrhythmias and congestive heart failure: a 25-year retrospective analysis from 1999 to 2024

  • 期刊论文

  • 发表日期：

    2026年3月26日

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  • Muhammad Abdullah Naveed,
  • Ahila Ali,
  • Shaheer Bin Shafiq,
  • Muhammad Junaid Razzak,
  • Muhammad Omer Rehan,
  • Muhammad Naveed Uz Zafar,
  • Rabia Iqbal,
  • Hamna Ali,
  • Bazil Azeem,
  • Mushood Ahmed,
  • Hamza Naveed,
  • Muhammad Zia Khan,
  • Sivaram Neppala,
  • Siddharth Agarwal,
  • Zain Ul Abideen Asad,
  • Muhammad Bilal Munir

摘要

Background

Congestive heart failure (CHF) complicated by ventricular arrhythmias (VA) continues to account for substantial mortality. Nevertheless, national-level longitudinal evidence on mortality trends remains limited. This study investigates these patterns among U.S. adults aged ≥ 25 years across years 1999–2024.

Methods

An observational analysis of U.S. mortalities due to VA with CHF (ICD-10 I47.2, I49.0 and I50.0 respectively), was conducted using CDC WONDER. Age-adjusted mortality rates (AAMRs) per 100,000 were calculated, and temporal trends were evaluated using annual percent change (APC) and average annual percent change (AAPC), stratified by year, age, sex, race, and geographic region.

Results

Between 1999 and 2024, 60,968 deaths were accounted for VA with CHF. Overall, AAMR declined from 1.8 in 1999 to 0.9 in 2024 (AAPC: − 2.36%; p < 0.001). A sharp decline occurred from 1999 to 2008 (APC: − 8.07; p < 0.001), followed by a significant increase afterwards (APC: 1.01; p = 0.0036). AAMRs were higher in men than women (1.7 vs. 0.6). Older adults showed greatest AAMRs (4.5) compared with middle-aged (0.5) and younger adults (0.1). By race, Non-Hispanic (NH) Blacks exhibited the highest mortality rates (1.4), followed by Whites (1.1), Hispanics (0.7), and NH Others (0.6). Geographically, West Virginia recorded the highest AAMR (1.8) versus New York (0.7). The West, Midwest, and South shared similar rates (1.1), whereas the Northeast was lowest (0.8). Rural populations demonstrated higher AAMRs than urban (1.2 vs. 1.0).

Conclusion

Although VA-CHF mortality has decreased over the past two decades, disparities by race, sex, age, and geography persist, underscoring the need for targeted healthcare strategies.