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Background <p>Single-shot ablation systems are widely used for pulmonary vein isolation (PVI) in atrial fibrillation (AF). The use of novel pulsed-field ablation (PFA) systems enables ablation beyond PVI, such as left atrial roof ablation (LARA), which may improve outcomes in persistent AF.</p> Objective <p>This study aimed to compare the acute efficacy, feasibility, and safety of PVI combined with LARA using three different single-shot ablation systems in patients with persistent AF and left atrial enlargement undergoing their first AF ablation.</p> Methods <p>Consecutive patients undergoing PVI with LARA using cryoballoon or PFA systems were included. Baseline characteristics, procedural parameters, and complication rates were assessed.</p> Results <p>We included 125 patients with persistent AF and left atrial dilation, divided into cryoballoon (<i>n</i> = 65), pentaspline PFA (<i>n</i> = 30), and circular PFA (<i>n</i> = 30) groups. Acute PVI was achieved in 100% of veins. Fewer applications were required for LARA with cryoballoon vs. PFA (4 vs. 8 vs. 10, <i>P</i> &lt; 0.001). Conduction block was confirmed in 95%, 100%, and 100% of patients (<i>P</i> = 0.421). Procedural times were longer with cryoballoon (87.0 vs. 64.0 vs. 68.0&#xa0;min, <i>P</i> &lt; 0.001), but fluoroscopy times were shorter (12.2 vs. 15.3 vs. 15.1&#xa0;min, <i>P</i> = 0.002). Contrast medium use was higher in the cryoballoon group (<i>P</i> &lt; 0.001). Adverse events were rare and predominantly minor, with three complications in the cryoballoon group and one in the PFA groups (<i>P</i> = 0.493).</p> Conclusion <p>All single-shot ablation systems demonstrated comparable efficacy and safety for PVI and LARA, with differences in procedural feasibility. Further and larger studies are needed.</p> Graphical Abstract <p></p>

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Acute outcomes of cryoballoon vs. circular vs. pentaspline pulsed-field ablation catheters in combined pulmonary vein isolation and roof line ablation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月29日

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  • Joerg Yogarajah,
  • Julie Hutter,
  • Patrick Kahle,
  • Philipp Beaujean,
  • Marko Tomic,
  • Andreas Hain,
  • Samuel Sossalla,
  • Thomas Neumann,
  • Malte Kuniss

摘要

Background

Single-shot ablation systems are widely used for pulmonary vein isolation (PVI) in atrial fibrillation (AF). The use of novel pulsed-field ablation (PFA) systems enables ablation beyond PVI, such as left atrial roof ablation (LARA), which may improve outcomes in persistent AF.

Objective

This study aimed to compare the acute efficacy, feasibility, and safety of PVI combined with LARA using three different single-shot ablation systems in patients with persistent AF and left atrial enlargement undergoing their first AF ablation.

Methods

Consecutive patients undergoing PVI with LARA using cryoballoon or PFA systems were included. Baseline characteristics, procedural parameters, and complication rates were assessed.

Results

We included 125 patients with persistent AF and left atrial dilation, divided into cryoballoon (n = 65), pentaspline PFA (n = 30), and circular PFA (n = 30) groups. Acute PVI was achieved in 100% of veins. Fewer applications were required for LARA with cryoballoon vs. PFA (4 vs. 8 vs. 10, P < 0.001). Conduction block was confirmed in 95%, 100%, and 100% of patients (P = 0.421). Procedural times were longer with cryoballoon (87.0 vs. 64.0 vs. 68.0 min, P < 0.001), but fluoroscopy times were shorter (12.2 vs. 15.3 vs. 15.1 min, P = 0.002). Contrast medium use was higher in the cryoballoon group (P < 0.001). Adverse events were rare and predominantly minor, with three complications in the cryoballoon group and one in the PFA groups (P = 0.493).

Conclusion

All single-shot ablation systems demonstrated comparable efficacy and safety for PVI and LARA, with differences in procedural feasibility. Further and larger studies are needed.

Graphical Abstract