<p>Parent-teen communication about sex and relationships supports healthy decision-making and well-being among teens. However, interpersonal communication is affected by specific cultural and place-based contexts. These sensitive conversations may be particularly challenging for families in rural and Latino communities due to limited sexual health knowledge and information, stigma, embarrassment, and social norms. Using a systems approach to interpersonal communication, this study aimed to explore communication around sensitive topics including sex, sexual health, dating, and relationships among mothers and teens living in predominately Latino rural communities. Nineteen mother-teen dyads (38 individuals) participated in semi-structured interviews in English or Spanish in rural Fresno County, California. Interviews were transcribed in the original language, coded, and analyzed thematically. Results found that all but one teen was satisfied or somewhat satisfied with their discussions about dating and sex with their parents, compared to a third of the mothers. Most mothers and teens reported discussing these topics, although conversations about dating were more common than about sex, which was often viewed as stressful and awkward by teens. Many mothers felt unprepared to initiate these conversations due to cultural norms, embarrassment, and insufficient knowledge. Teens valued informative, open, and non-judgmental discussions that address both positive and negative aspects of sex and dating. Findings suggest that while mothers and teens are willing to engage in these conversations, they need additional tools and resources. Programs that incorporate culturally relevant discussions on intergenerational influences, gender norms, and communication strategies may help strengthen mother-teen dialogue and improve adolescent sexual health outcomes.</p>