<p>Dementia-related anxiety (DRA) involves the fear of having or developing dementia. A previous latent profile analysis identified sub-groups of participants with shared patterns of DRA revealed that self-perceived dementia risk, preparedness for future care, health-related anxiety, age, dementia exposure, and anticipated dementia stigma contributed to differences in DRA among a U.S. sample. This study aimed to replicate the findings among Israeli adults and expand them by determining whether objective knowledge about dementia is an indicator of DRA. Israeli Jewish adults (<i>N</i> = 280, <i>M</i>_<i>age</i> = 41.6) completed online assessments. Two profiles emerged, differing primarily by DRA and preparedness for future care. Health-related anxiety and dementia exposure contributed less, and objective knowledge did not contribute to profile differences. We consider profile differences between U.S. and Israeli samples within their cultural contexts and close with attention to the importance of person-centered approaches to develop and deliver effective interventions addressing elevated DRA.</p>