<p>This study examines the multidimensional aspects of quality of life (QoL) among octogenarians in Nigeria, with a view to understanding their levels of satisfaction across different domains. Conducted in four states, namely Osun, Oyo, Imo, and Benue, the research employed a cross-sectional, community-based design to gather primary data from 1,774 octogenarians. The World Health Organisation’s pre-designed questionnaire for older individuals was adapted and utilised to capture various dimensions of QoL, including physical, psychological, social, environmental, and spiritual aspects. Findings reveal significant differences in QoL across demographic factors such as sex, religion, marital status, and location. Factors like disability, sex, religion, marital status, and locality were identified as significant determinants impacting octogenarians’ QoL in different dimensions. Notably, octogenarians generally reported average to high satisfaction levels across various dimensions of their QoL, particularly in social relationships and environmental conditions. The study underscores the importance of community and interpersonal connections in promoting positive QoL among octogenarians. Furthermore, it highlights the need for personalised approaches to address psychological well-being and spirituality, as these dimensions exhibit varying levels of satisfaction among respondents. Overall, the findings suggest a generally positive QoL among octogenarians in Nigeria, with opportunities for enhancing psychological support and tailoring interventions to individual spiritual needs. This research contributes to understanding the nuanced dynamics of QoL among octogenarians in Nigeria, providing insights for policymakers and healthcare professionals to develop targeted interventions that promote holistic well-being in this age group.</p>