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<p>The formation of inclusion complexes of the (6-FAM)<sub>2</sub> bifluorophore with α-, β-, and γ-cyclodextrins in phosphate buffer solution (pH 9.0) was studied by spectrophotometry and fluorimetry. The association constants and Gibbs free energy changes for 1:1 stoichiometry was determined. The highest association constant was observed for the complex with β-cyclodextrin, which was explained by the optimal spatial match between the guest molecule and the host cavity. The effect of the (6-FAM)<sub>2</sub>/β-CD inclusion complex on the fluorescent response of the system in the presence of protein (bovine serum albumin) was shown.</p>

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Spectral Investigations of Inclusion Complexes of a Fluorescein Bifluorophore with α-, β-, and γ-Cyclodextrins

  • 期刊论文

  • 发表日期：

    2026年7月22日

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  • H. S. Pilipovich,
  • F. Fan,
  • I. I. Lisenko,
  • V. A. Povedailo,
  • S. A. Tikhomirov,
  • V. V. Shmanai

摘要

The formation of inclusion complexes of the (6-FAM)2 bifluorophore with α-, β-, and γ-cyclodextrins in phosphate buffer solution (pH 9.0) was studied by spectrophotometry and fluorimetry. The association constants and Gibbs free energy changes for 1:1 stoichiometry was determined. The highest association constant was observed for the complex with β-cyclodextrin, which was explained by the optimal spatial match between the guest molecule and the host cavity. The effect of the (6-FAM)2/β-CD inclusion complex on the fluorescent response of the system in the presence of protein (bovine serum albumin) was shown.