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<p>Seratrodast is a 1,4-benzoquinone derivative belonging to the class of thromboxane A2 (TXA2) receptor antagonists and is employed for prophylactic management of asthma. The present report describes the validation of quick, simple, sensitive, and cost-effective zero-order, first-order, and second-order derivative spectrophotometric methods for the estimation of seratrodast in bulk and in its marketed tablet formulation. Exhaustive spectrophotometric analysis of the drug was carried out using a total of 23 parametric variations, which were evaluated in acetonitrile. Three selected method variants were assessed for their stability, indicating potential regarding stress-degraded solutions of the drug. The developed methods were validated with respect to linearity, accuracy, precision, and robustness. Excellent linearity was observed in the concentration range of 5.0–50.0 μg/mL with correlation coefficients above 0.999. The limits of detection were found to range from 0.54 to 0.70 μg/mL, and quantitation limits ranged from 1.66 to 2.14 μg/mL for the proposed method variants. The proposed methods were also employed for the assay of seratrodast in its marketed tablet formulation, and good recoveries ranging from 96.23 to 98.68% were obtained.</p>

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Derivative Spectrophotometric Methods for Estimation of Seratrodast in Bulk and in Formulation

  • 期刊论文

  • 发表日期：

    2026年2月27日

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  • Kanade Krushna Devrao,
  • Alka Bali,
  • Priyanshi Sharma

摘要

Seratrodast is a 1,4-benzoquinone derivative belonging to the class of thromboxane A2 (TXA2) receptor antagonists and is employed for prophylactic management of asthma. The present report describes the validation of quick, simple, sensitive, and cost-effective zero-order, first-order, and second-order derivative spectrophotometric methods for the estimation of seratrodast in bulk and in its marketed tablet formulation. Exhaustive spectrophotometric analysis of the drug was carried out using a total of 23 parametric variations, which were evaluated in acetonitrile. Three selected method variants were assessed for their stability, indicating potential regarding stress-degraded solutions of the drug. The developed methods were validated with respect to linearity, accuracy, precision, and robustness. Excellent linearity was observed in the concentration range of 5.0–50.0 μg/mL with correlation coefficients above 0.999. The limits of detection were found to range from 0.54 to 0.70 μg/mL, and quantitation limits ranged from 1.66 to 2.14 μg/mL for the proposed method variants. The proposed methods were also employed for the assay of seratrodast in its marketed tablet formulation, and good recoveries ranging from 96.23 to 98.68% were obtained.