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<p>Silver nanoparticles (Ag NPs) were synthesized by using the extract of almond kernels as a natural reducing and stabilizing agent. The synthesized Ag NPs were characterized by UV-Vis spectrophotometer, FTIR spectroscopy, XRD characterization, and TEM imaging. As a result, every technique showed that the particle size of Ag NPs was 18–23 nm. It also showed that the synthesized Ag NPs exhibited a moderate cytotoxic effect on normal human fibroblast cell line (BJ1), IC<sub>50</sub> was 98.4 μg/mL. According to quantitative PCR (qPCR) data, which evaluate the expression of two virulence-related genes, ALS3 and HWP1, in Candida albicans, it was shown that the synthesized Ag NPs suppresses the expression of the main virulence genes of Candida albicans more effectively (1.5 times for ALS3 and 1.2 times for HWP1) than miconazole cream. In vivo, in rats, it was shown that Ag NPs also effectively reduced the fungal load in infected skin tissues over time.</p>

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Biogenic Silver Nanoparticles Synthesized Using Almond Extract: Physicochemical Properties and Antifungal Efficacy Against Candida albicans

  • 期刊论文

  • 发表日期：

    2026年1月16日

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  • Mohammed Elywa,
  • Marwa Abd El-Hamid,
  • Toqa Adel,
  • Magda Hanafy

摘要

Silver nanoparticles (Ag NPs) were synthesized by using the extract of almond kernels as a natural reducing and stabilizing agent. The synthesized Ag NPs were characterized by UV-Vis spectrophotometer, FTIR spectroscopy, XRD characterization, and TEM imaging. As a result, every technique showed that the particle size of Ag NPs was 18–23 nm. It also showed that the synthesized Ag NPs exhibited a moderate cytotoxic effect on normal human fibroblast cell line (BJ1), IC50 was 98.4 μg/mL. According to quantitative PCR (qPCR) data, which evaluate the expression of two virulence-related genes, ALS3 and HWP1, in Candida albicans, it was shown that the synthesized Ag NPs suppresses the expression of the main virulence genes of Candida albicans more effectively (1.5 times for ALS3 and 1.2 times for HWP1) than miconazole cream. In vivo, in rats, it was shown that Ag NPs also effectively reduced the fungal load in infected skin tissues over time.