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<p><i>Ecklonia cava</i>, an edible brown seaweed, is a rich source of phlorotannins with diverse biological activities and industrial applicability. In this study, dioxinodehydroeckol (DD) was isolated from <i>E. cava</i> through methanolic extraction, solvent partitioning, and sequential chromatographic purification of the ethyl acetate fraction, followed by structural identification using NMR spectroscopy. We then evaluated the applied functional potential of DD as a marine algae–derived anti-inflammatory ingredient for cosmetic and dermatological use. DD markedly reduced the production of the pro-inflammatory cytokines IL-6 and IL-8 in keratinocytes stimulated by <i>Cutibacterium acnes</i>, a major aggravating factor of inflammatory skin conditions. Mechanistically, DD attenuated <i>C. acnes</i>-induced activation of intracellular signaling pathways, including ERK, AKT, and nuclear NF-κB, thereby suppressing downstream inflammatory responses. These findings demonstrate that DD modulates core inflammatory pathways relevant to skin irritation and highlight its value as a functional phlorotannin derived from brown seaweed. Overall, this study supports the potential of <i>E. cava</i>–derived DD as a phycological resource–based, non-antibiotic bioactive ingredient for the development of natural anti-inflammatory formulations in the cosmetic and cosmeceutical industries.</p>

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Anti-inflammatory activity of dioxinodehydroeckol from Ecklonia cava in Cutibacterium acnes-induced HaCaT cells by suppressing the MAPKs and NF-κB signaling pathway

  • 期刊论文

  • 发表日期：

    2026年4月2日

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  • Eun-Song Kim,
  • Ji-Yul Kim,
  • Mi-Jin Yim,
  • Chul Hwan Kim,
  • Jeong Min Lee,
  • Dae-Sung Lee,
  • Il-Whan Choi,
  • Kil Bo Shim,
  • Young-Mog Kim,
  • Sung-Hwan Eom

摘要

Ecklonia cava, an edible brown seaweed, is a rich source of phlorotannins with diverse biological activities and industrial applicability. In this study, dioxinodehydroeckol (DD) was isolated from E. cava through methanolic extraction, solvent partitioning, and sequential chromatographic purification of the ethyl acetate fraction, followed by structural identification using NMR spectroscopy. We then evaluated the applied functional potential of DD as a marine algae–derived anti-inflammatory ingredient for cosmetic and dermatological use. DD markedly reduced the production of the pro-inflammatory cytokines IL-6 and IL-8 in keratinocytes stimulated by Cutibacterium acnes, a major aggravating factor of inflammatory skin conditions. Mechanistically, DD attenuated C. acnes-induced activation of intracellular signaling pathways, including ERK, AKT, and nuclear NF-κB, thereby suppressing downstream inflammatory responses. These findings demonstrate that DD modulates core inflammatory pathways relevant to skin irritation and highlight its value as a functional phlorotannin derived from brown seaweed. Overall, this study supports the potential of E. cava–derived DD as a phycological resource–based, non-antibiotic bioactive ingredient for the development of natural anti-inflammatory formulations in the cosmetic and cosmeceutical industries.