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<p>Dry eye syndrome (DES) is a prevalent condition that causes corneal damage and discomfort due to dryness. This study investigates <i>Tetraselmis chuii</i>, a novel food ingredient rich in polyunsaturated fatty acids (PUFAs) and carotenoids, for its potential role in DES prevention. Using a scopolamine-induced DES model in BALB/c mice, <i>T. chuii</i> administration increased corneal thickness and tear volume while reducing lacrimal gland tissue damage. Additionally, it inhibited immune cell infiltration in conjunctival and lacrimal gland tissue in a dose-dependent manner, suggesting a reduction in immune cell migration and activation. Western blot and RNA sequencing analyses showed that <i>T. chuii</i> suppressed pro-inflammatory cytokines and immune cell migration markers, modulating inflammation and immune-related gene expression. These results indicate that <i>T. chuii</i> supports ocular health by reducing inflammation and regulating immune responses, making it a promising natural therapeutic for DES treatment and prevention.</p>

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Mechanism of dry eye syndrome improvement by Tetraselmis chuii: Anti-inflammatory effects and ocular mucous membrane restoration

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月28日

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  • Sung-Chul Hong,
  • Jin-Woo Kim,
  • Eun Ha Lee,
  • Chi Rac Hong,
  • Jaeyoung Choi,
  • Pahn-Shick Chang,
  • Jin-Chul Kim

摘要

Dry eye syndrome (DES) is a prevalent condition that causes corneal damage and discomfort due to dryness. This study investigates Tetraselmis chuii, a novel food ingredient rich in polyunsaturated fatty acids (PUFAs) and carotenoids, for its potential role in DES prevention. Using a scopolamine-induced DES model in BALB/c mice, T. chuii administration increased corneal thickness and tear volume while reducing lacrimal gland tissue damage. Additionally, it inhibited immune cell infiltration in conjunctival and lacrimal gland tissue in a dose-dependent manner, suggesting a reduction in immune cell migration and activation. Western blot and RNA sequencing analyses showed that T. chuii suppressed pro-inflammatory cytokines and immune cell migration markers, modulating inflammation and immune-related gene expression. These results indicate that T. chuii supports ocular health by reducing inflammation and regulating immune responses, making it a promising natural therapeutic for DES treatment and prevention.