Purpose <p>Autism is a neurodevelopmental disorder that is globally increasing in prevalence. It presents significant challenges, particularly for mothers of children with autism. While extensive research has examined the lived experiences of these mothers in various global contexts, the gap remains in understanding this phenomenon in Palestine, particularly in the West Bank.&#xa0;This study aims to explore the lived experiences of mothers of children with ASD, shedding light on their struggles, challenges, and coping mechanisms.</p> Methods <p>A qualitative phenomenological hermeneutics design was employed, recruiting sixteen mothers purposively including mothers from various age groups, educational backgrounds, and residential areas across different districts in the West Bank to ensure a diverse sample. Data were collected using in-depth, semi-structured interviews between February and April 2024. The interviews were analyzed using a phenomenological hermeneutics approach to uncover and interpret the meaning of the mothers’ experiences.</p> Results <p>The lived experience of mothers of children with Autism was conveyed in ten subthemes. These subthemes were formulated in condensed descriptions to assemble these three themes: difficult and overwhelming experiences, caregiving challenging and burden, and building resilience.</p> Conclusion <p>There is a great need for more comprehensive healthcare and social systems that prioritize the unique needs of families with children with autism in the West Bank. Policies and programs should focus on increasing autism awareness, improving access to specialized services, and providing psychological and financial support to mothers and caregivers.</p>