<p>Despite evidence indicating that antisemitism is a significant and growing form of discrimination, there is a dearth of research on the impact of antisemitism on mental health in Jewish populations. This article presents findings from the first known quantitative study on perceived antisemitism and mental health in Jewish women and their children. Specifically, we investigate the relationship between perceived discrimination and, primarily, externalizing, and, secondarily, internalizing symptoms mediated by both parental psychopathology and negative parenting behaviors. A total of 228 Jewish mothers (M_age = 36.79, SD = 5.18) residing in the United States participated in this study and answered questions about a single preschool-age child (2–5&#xa0;years; M_age = 3.90, SD = 1.01, female = 113). We observed significant positive associations between maternal perceived antisemitism (MPA) and both maternal and child psychopathology. Using structural equation modeling, we established that maternal psychopathology significantly mediated the relationship between MPA and children’s total externalizing and internalizing symptoms but not callous-unemotional (CU) traits. Parenting behaviors were found to significantly mediate the relationship between MPA and CU traits. This study also included an initial evaluation of several novel assessments of perceived antisemitism. According to these assessments, more than 78% of participants reported having felt unsafe to be identifiably Jewish in public settings for fear of physical harassment, highlighting the pervasiveness of reported perceptions of antisemitic experiences. The findings underscore the need for further research on antisemitism and mental health outcomes in Jewish communities in the diaspora, particularly among children.</p>