Scholarlink

Purpose <p>Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness globally. Emerging evidence suggests glaucoma is a vasculopathy with associated systemic microvascular dysfunction. A known feature of endothelial dysfunction is transudation, typified by albuminuria. This aimed to determine the relationship between POAG and albuminuria in patients attending a Nigerian tertiary hospital with a view to enhancing the evaluation and management of POAG patients for blindness prevention, particularly in resource-limited settings.</p> Methods <p>This hospital-based, comparative cross-sectional study included 210 adults: 105 POAG patients and 105 age—and sex-matched non-glaucomatous participants. Data on demographics and medical history were collected using an interviewer-administered questionnaire. Blood samples were analyzed for fasting blood sugar, lipid profile, and estimated glomerular filtration rate (GFR). Spot urine samples were collected to determine albuminuria using the urinary albumin-to-creatinine ratio (UACR, mg/g), based on measurements of urinary albumin and creatinine.</p> Results <p>A total of 210 patients were enrolled. These included 45 males and 60 females in each study and control group (male-to-female ratio of 1:1.3). The mean age of POAG participants was 43.91 ± 14.8&#xa0;years. Among POAG participants, 69 (65.7%) had mild, 26 (24.8%) had moderate, and 10 (9.5%) had severe POAG. A significantly higher proportion of albuminuria was observed in the POAG group (8 patients, 7.6%) compared to the non-glaucoma group (3 patients, 2.9%) (<i>p</i> = <i>0.049</i>). The odds of albuminuria were nearly three times higher in participants with severe POAG compared to those with mild POAG (OR = 2.993; 95% CI, 1.003–7.574; <i>p</i> = 0.048), and participants with POAG were approximately 2.5 times more likely to have albuminuria compared to the non-glaucoma group (OR = 2.483; 95% CI, 1.071–4.552; <i>p</i> = 0.042). Median UACR was significantly higher in the POAG group (7.69&#xa0;mg/g; interquartile range [6.2–10.3]) compared to the non-glaucoma group (3.83&#xa0;mg/g; range [1.7–9.3]) (<i>p</i> &lt; 0.001).</p> Conclusion <p>This study demonstrated a significant association between POAG and albuminuria, with increasing severity of POAG correlating with higher odds of albuminuria. These findings suggest that albuminuria could serve as a systemic marker of disease severity in POAG. Early identification and monitoring of albuminuria in glaucoma patients may improve disease management and outcomes, potentially reducing the incidence of blindness.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Relationship between albuminuria and primary open angle glaucoma in patients attending a Nigerian tertiary hospital

  • 期刊论文

  • 发表日期：

    2026年7月9日

查看全文
  • Ademola Ayoda Sule,
  • Adetunji Olusesan Adenekan,
  • Adegboyega Sunday Alabi,
  • Obiefuna Ajie,
  • Oluwatobi Idowu,
  • Judith Ogechi Anikwenwa,
  • Kareem Olatunbosun Musa,
  • Adeola Olukorede Onakoya

摘要

Purpose

Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness globally. Emerging evidence suggests glaucoma is a vasculopathy with associated systemic microvascular dysfunction. A known feature of endothelial dysfunction is transudation, typified by albuminuria. This aimed to determine the relationship between POAG and albuminuria in patients attending a Nigerian tertiary hospital with a view to enhancing the evaluation and management of POAG patients for blindness prevention, particularly in resource-limited settings.

Methods

This hospital-based, comparative cross-sectional study included 210 adults: 105 POAG patients and 105 age—and sex-matched non-glaucomatous participants. Data on demographics and medical history were collected using an interviewer-administered questionnaire. Blood samples were analyzed for fasting blood sugar, lipid profile, and estimated glomerular filtration rate (GFR). Spot urine samples were collected to determine albuminuria using the urinary albumin-to-creatinine ratio (UACR, mg/g), based on measurements of urinary albumin and creatinine.

Results

A total of 210 patients were enrolled. These included 45 males and 60 females in each study and control group (male-to-female ratio of 1:1.3). The mean age of POAG participants was 43.91 ± 14.8 years. Among POAG participants, 69 (65.7%) had mild, 26 (24.8%) had moderate, and 10 (9.5%) had severe POAG. A significantly higher proportion of albuminuria was observed in the POAG group (8 patients, 7.6%) compared to the non-glaucoma group (3 patients, 2.9%) (p = 0.049). The odds of albuminuria were nearly three times higher in participants with severe POAG compared to those with mild POAG (OR = 2.993; 95% CI, 1.003–7.574; p = 0.048), and participants with POAG were approximately 2.5 times more likely to have albuminuria compared to the non-glaucoma group (OR = 2.483; 95% CI, 1.071–4.552; p = 0.042). Median UACR was significantly higher in the POAG group (7.69 mg/g; interquartile range [6.2–10.3]) compared to the non-glaucoma group (3.83 mg/g; range [1.7–9.3]) (p < 0.001).

Conclusion

This study demonstrated a significant association between POAG and albuminuria, with increasing severity of POAG correlating with higher odds of albuminuria. These findings suggest that albuminuria could serve as a systemic marker of disease severity in POAG. Early identification and monitoring of albuminuria in glaucoma patients may improve disease management and outcomes, potentially reducing the incidence of blindness.