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Purpose <p>To assess the dynamics of Pattern Electroretinogram (PERG) parameters following glaucoma surgery in individuals with glaucomatous optic neuropathy.</p> Methods <p>The is a single center retrospective study. Preoperative PERG were conducted on moderate and advanced glaucoma patients scheduled for glaucoma surgery. Subsequently, the patients underwent an additional PERG a few months after the procedure. Comparative analysis focused on the PERG parameters (Mag, MagD and MagD/Mag ratio) before and after the glaucoma surgery in eyes achieving successful intraocular pressure (IOP) reduction post-operatively.</p> Results <p>The study enrolled 23 eyes from 21 consecutive patients who underwent successful glaucoma surgery between January 2021 and December 2023, each with both pre and post-operative PERG assessments. Postoperatively, there was a significant improvement of all the PERG parameters (0.97 ± 0.29 to 1.36 ± 0.29&#xa0;μV, 0.55 ± 0.3 to 0.84 ± 0.42&#xa0;μV, 0.52 ± 0.2 to 0.68 ± 0.25 for Mag, MagD and MagD/Mag ratio respectively, all <i>p</i> &lt; 0.05). Three patients who had no IOP reduction postoperatively showed no improvement of all PERG parameters following the surgery.</p> Conclusions <p>Glaucoma surgery, leading to effective IOP reduction, may demonstrate a positive impact on the functional activity of the retinal ganglion cells, as evidenced by the enhancement in PERG parameters post-operatively.</p>

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Improvement of pattern electroretinogram parameters following glaucoma surgery

  • 期刊论文

  • 发表日期：

    2026年6月24日

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  • Emmanuel Bettach,
  • Leandro Oliverio,
  • Kaweh Mansouri,
  • André Mermoud

摘要

Purpose

To assess the dynamics of Pattern Electroretinogram (PERG) parameters following glaucoma surgery in individuals with glaucomatous optic neuropathy.

Methods

The is a single center retrospective study. Preoperative PERG were conducted on moderate and advanced glaucoma patients scheduled for glaucoma surgery. Subsequently, the patients underwent an additional PERG a few months after the procedure. Comparative analysis focused on the PERG parameters (Mag, MagD and MagD/Mag ratio) before and after the glaucoma surgery in eyes achieving successful intraocular pressure (IOP) reduction post-operatively.

Results

The study enrolled 23 eyes from 21 consecutive patients who underwent successful glaucoma surgery between January 2021 and December 2023, each with both pre and post-operative PERG assessments. Postoperatively, there was a significant improvement of all the PERG parameters (0.97 ± 0.29 to 1.36 ± 0.29 μV, 0.55 ± 0.3 to 0.84 ± 0.42 μV, 0.52 ± 0.2 to 0.68 ± 0.25 for Mag, MagD and MagD/Mag ratio respectively, all p < 0.05). Three patients who had no IOP reduction postoperatively showed no improvement of all PERG parameters following the surgery.

Conclusions

Glaucoma surgery, leading to effective IOP reduction, may demonstrate a positive impact on the functional activity of the retinal ganglion cells, as evidenced by the enhancement in PERG parameters post-operatively.