Scholarlink

Purpose <p>Diabetic retinopathy (DR) is a major cause of vision impairment worldwide. Widefield optical coherence tomography angiography (WF-OCTA) is a non-invasive alternative to widefield fluorescein angiography (WF-FA) that provides high-resolution imaging of retinal vasculature. This systematic review evaluates the diagnostic performance of WF-FA and ultra-widefield (UWF)-FA vs. WF-OCTA and UWF-OCTA in detecting DR-related retinal vascular changes.</p> Methods <p>A systematic search was conducted, following PRISMA guidelines. Studies reporting quantitative or qualitative findings on microaneurysms (MAs), intra-retinal microvascular abnormalities (IRMAs), and neovascularization (NV), or foveal avascular zone (FAZ) changes were analyzed.</p> Results <p>A total of 12 studies (648 eyes) met the inclusion criteria. Findings suggest that WF-OCTA detect NV with high sensitivity (96.55%) and specificity (94.74%), comparable to WF-FA. However, WF-FA showed potential in certain qualitative aspects, suggesting a possible complementary role.</p> Conclusion <p>WF-OCTA and UWF-OCTA are promising non-invasive alternatives to WF-FA and UWF-FA, offering high diagnostic accuracy, rapid imaging, and depth-resolved vascular analysis.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Comparing widefield and ultra-widefield optical coherence tomography angiography with fluorescein angiography in diabetic retinopathy: a review

  • 期刊论文

  • 发表日期：

    2026年2月12日

查看全文
  • Parva Pourbagherkhah,
  • Hemn Baghban Jaldian

摘要

Purpose

Diabetic retinopathy (DR) is a major cause of vision impairment worldwide. Widefield optical coherence tomography angiography (WF-OCTA) is a non-invasive alternative to widefield fluorescein angiography (WF-FA) that provides high-resolution imaging of retinal vasculature. This systematic review evaluates the diagnostic performance of WF-FA and ultra-widefield (UWF)-FA vs. WF-OCTA and UWF-OCTA in detecting DR-related retinal vascular changes.

Methods

A systematic search was conducted, following PRISMA guidelines. Studies reporting quantitative or qualitative findings on microaneurysms (MAs), intra-retinal microvascular abnormalities (IRMAs), and neovascularization (NV), or foveal avascular zone (FAZ) changes were analyzed.

Results

A total of 12 studies (648 eyes) met the inclusion criteria. Findings suggest that WF-OCTA detect NV with high sensitivity (96.55%) and specificity (94.74%), comparable to WF-FA. However, WF-FA showed potential in certain qualitative aspects, suggesting a possible complementary role.

Conclusion

WF-OCTA and UWF-OCTA are promising non-invasive alternatives to WF-FA and UWF-FA, offering high diagnostic accuracy, rapid imaging, and depth-resolved vascular analysis.