Scholarlink

Purpose <p>To compare the functional and anatomical outcomes of pars plana vitrectomy (PPV) with or without internal limiting membrane (ILM) peeling in patients suffering with non-resolving vitreous hemorrhage and tractional retinal detachment.</p> Methods <p>Fifty-seven patients (57 eyes) suffering from PDR were randomly assigned to undergo PPV with ILM peeling (n = 26) or without ILM peeling (n = 31). Outcomes assessed over a 6-month follow-up included best-corrected visual acuity (BCVA), need for additional anti-VEGF injections, frequency of reoperations, central macular thickness (CMT), development of epiretinal membrane (ERM), macular traction, and vascular parameters derived from OCT imaging.</p> Results <p>Both groups showed statistically significant improvements in BCVA postoperatively (<i>p</i> &lt; 0.001), with no significant difference between them (<i>p</i> = 0.846). The ILM peeling group required fewer repeat anti-VEGF injections (7.7% vs. 35.5%, <i>p</i> = 0.030) and exhibited a significantly lower incidence of secondary ERM (11.5% vs. 51.6%, <i>p</i> = 0.004). ERM formation correlated with iatrogenic retinal tears (<i>p</i> = 0.007) and tractional retinal detachment (TRD) (<i>p</i> &lt; 0.001). Reoperations for ERM removal occurred exclusively in the non-ILM peeling group. No significant intergroup differences were found in CMT, foveal avascular zone (FAZ) area, or vessel density.</p> Conclusion <p>ILM peeling during diabetic vitrectomy effectively minimizes the risk of postoperative ERM formation and reduces the need for further Anti-VEGF injections for DME. However, it does not confer a significant advantage in terms of visual acuity improvements.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Outcome of pars plana vitrectomy with and without internal limiting membrane peeling in proliferative diabetic retinopathy

  • 期刊论文

  • 发表日期：

    2026年1月21日

查看全文
  • Omar Abdelkarem Hasan,
  • Mohamed Sharaf Ghoneima,
  • Ahmad Abdelnasser Awad,
  • Zeiad Hasan Eldaly,
  • Wael Mohamed Soliman

摘要

Purpose

To compare the functional and anatomical outcomes of pars plana vitrectomy (PPV) with or without internal limiting membrane (ILM) peeling in patients suffering with non-resolving vitreous hemorrhage and tractional retinal detachment.

Methods

Fifty-seven patients (57 eyes) suffering from PDR were randomly assigned to undergo PPV with ILM peeling (n = 26) or without ILM peeling (n = 31). Outcomes assessed over a 6-month follow-up included best-corrected visual acuity (BCVA), need for additional anti-VEGF injections, frequency of reoperations, central macular thickness (CMT), development of epiretinal membrane (ERM), macular traction, and vascular parameters derived from OCT imaging.

Results

Both groups showed statistically significant improvements in BCVA postoperatively (p < 0.001), with no significant difference between them (p = 0.846). The ILM peeling group required fewer repeat anti-VEGF injections (7.7% vs. 35.5%, p = 0.030) and exhibited a significantly lower incidence of secondary ERM (11.5% vs. 51.6%, p = 0.004). ERM formation correlated with iatrogenic retinal tears (p = 0.007) and tractional retinal detachment (TRD) (p < 0.001). Reoperations for ERM removal occurred exclusively in the non-ILM peeling group. No significant intergroup differences were found in CMT, foveal avascular zone (FAZ) area, or vessel density.

Conclusion

ILM peeling during diabetic vitrectomy effectively minimizes the risk of postoperative ERM formation and reduces the need for further Anti-VEGF injections for DME. However, it does not confer a significant advantage in terms of visual acuity improvements.