Purpose <p>Micropulse Transcleral Cyclophotocoagulation (MP-TSCPC) lowers intraocular pressure by directing bursts of energy at the ciliary body which leads to a reduction in aqueous production. Although the diode laser radiation has a propensity for melanin in the ciliary epithelium, some energy dissipates into surrounding tissues. This study aims to investigate the ocular effects of MP-TSCPC on patients with glaucoma, focusing on corneal biomechanics, endothelial cell count, and refractive outcomes.</p> Methods <p>Patients with open angle glaucoma and ocular hypertension were enrolled. Comprehensive ophthalmic investigations, including endothelial cell count, corneal topography, pupil diameter, and refraction, were conducted at baseline and six months post-MP-TSCPC.</p> Results <p>Thirty-one eyes of 31 patients were included. At six months post-MP-TSCPC, a 2% decrease in corneal endothelial cell density was noted, though not statistically significant. A modest hyperopic shift in spherical equivalent was observed at 6&#xa0;months and initially reached statistical significance. However, this did not remain significant following adjustment for multiple comparisons. Three patients had a significant hypermetropic shift. There was a statistically significant increase in pupil diameter.</p> Conclusion <p>This is the first study to review various ocular parameters following micropulse transcleral cyclophotocoagulation. Overall, there was minimal clinically significant impact on ocular parameters.</p>