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Purpose <p>To investigate long-term outcomes and their predictive factors in Chinese patients with proliferative diabetic retinopathy (PDR) after vitrectomy.</p> Study design <p>Retrospective and observational.</p> Methods <p>PDR patients who underwent vitrectomy in a tertiary eye hospital from 2010 to 2020 were enrolled. The cumulative incidences of re-vitrectomy in the primary eye, vitrectomy in the contralateral eye, low vision (&lt; 0.3 Snellen), and postoperative complications were calculated.</p> Results <p>A total of 1094 patients were included in the analysis. The 1-, 3-, and 5-year cumulative incidences for low vision in both eyes were 18.9%, 34.7%, and 44.4%, respectively. The 1-, 5-, and 10-year cumulative incidences for re-vitrectomy in the primary eye were 7.4%, 9.9%, and 9.9%, respectively, and for vitrectomy in the contralateral eye were 31.0%, 62.7%, and 79.5%, respectively. Vitrectomy in the contralateral eye was associated with younger age (hazard ratio [HR] = 0.99, 95% confidence interval [CI] 0.98–0.99), higher glycated hemoglobin (HR = 1.17, 95% CI 1.08–1.27), no preoperative photocoagulation (HR = 0.55, 95% CI 0.39–0.78), severer diabetic retinopathy level (HR = 2.28, 95% CI 1.56–3.33), and poorer preoperative vision (HR = 1.35, 95% CI 1.14–1.61). The cumulative postoperative incidences of the primary eye at 1, 5, and 10&#xa0;years were 5.7%, 9.9%, and 9.9% for vitreous hemorrhage, 4.2%, 5.1%, and 5.1% for retinal detachment, and 2.8%, 6.2%, and 8.1% for neovascular glaucoma, respectively.</p> Conclusion <p>This study reported a comprehensive post-vitrectomy incidence and predictive factors in Chinese PDR patients in a long-term follow up. This would aid in the clinical understanding of this lifelong disease.</p>

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Long-term outcomes of vitrectomy for proliferative diabetic retinopathy: a real world study in China

  • 期刊论文

  • 发表日期：

    2025年8月30日

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  • Jinghao Mei,
  • Hantao Zhou,
  • Chuying Deng,
  • Shimeng Wang,
  • Binghua Guo,
  • Wei Lin,
  • Zushun Lin,
  • Ke Lin,
  • Ronghan Wu,
  • Zhong Lin

摘要

Purpose

To investigate long-term outcomes and their predictive factors in Chinese patients with proliferative diabetic retinopathy (PDR) after vitrectomy.

Study design

Retrospective and observational.

Methods

PDR patients who underwent vitrectomy in a tertiary eye hospital from 2010 to 2020 were enrolled. The cumulative incidences of re-vitrectomy in the primary eye, vitrectomy in the contralateral eye, low vision (< 0.3 Snellen), and postoperative complications were calculated.

Results

A total of 1094 patients were included in the analysis. The 1-, 3-, and 5-year cumulative incidences for low vision in both eyes were 18.9%, 34.7%, and 44.4%, respectively. The 1-, 5-, and 10-year cumulative incidences for re-vitrectomy in the primary eye were 7.4%, 9.9%, and 9.9%, respectively, and for vitrectomy in the contralateral eye were 31.0%, 62.7%, and 79.5%, respectively. Vitrectomy in the contralateral eye was associated with younger age (hazard ratio [HR] = 0.99, 95% confidence interval [CI] 0.98–0.99), higher glycated hemoglobin (HR = 1.17, 95% CI 1.08–1.27), no preoperative photocoagulation (HR = 0.55, 95% CI 0.39–0.78), severer diabetic retinopathy level (HR = 2.28, 95% CI 1.56–3.33), and poorer preoperative vision (HR = 1.35, 95% CI 1.14–1.61). The cumulative postoperative incidences of the primary eye at 1, 5, and 10 years were 5.7%, 9.9%, and 9.9% for vitreous hemorrhage, 4.2%, 5.1%, and 5.1% for retinal detachment, and 2.8%, 6.2%, and 8.1% for neovascular glaucoma, respectively.

Conclusion

This study reported a comprehensive post-vitrectomy incidence and predictive factors in Chinese PDR patients in a long-term follow up. This would aid in the clinical understanding of this lifelong disease.