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Purposes <p>Parry-Romberg syndrome is a rare degenerative disease. This article focuses on the ocular aspects of Parry-Romberg syndrome to help diagnose and further explore more effective treatments.</p> Methods <p>A combined systematic search of PubMed electronic database by using Boolean operators AND and OR was conducted, choosing the following keywords: "Parry-Romberg syndrome", "Progressive hemifacial atrophy", "eye", "oculus", "ophthalmic", "ophthalmologic", "ophthalmology" and "global", etc. After the initial screening of these articles, repetitive literatures were excluded.</p> Results <p>69 articles were selected. This study introduces the ocular manifestations, possible pathogenesis, and treatment progress of Parry-Romberg syndrome.</p> Conclusion <p>There is currently no clear pathogenesis and effective treatment for Parry-Romberg syndrome. Understanding its pathological mechanism in the context of autoimmune etiology and exploring its phenotype-genotype correlation may help find more valuable treatments.</p>

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Ocular manifestations and treatment progress of Parry-Romberg syndrome

  • 期刊论文

  • 发表日期：

    2025年5月17日

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  • Dengfeng Zhang,
  • Shuting Huang,
  • Xin Zhang,
  • Le Ling,
  • Bei Li

摘要

Purposes

Parry-Romberg syndrome is a rare degenerative disease. This article focuses on the ocular aspects of Parry-Romberg syndrome to help diagnose and further explore more effective treatments.

Methods

A combined systematic search of PubMed electronic database by using Boolean operators AND and OR was conducted, choosing the following keywords: "Parry-Romberg syndrome", "Progressive hemifacial atrophy", "eye", "oculus", "ophthalmic", "ophthalmologic", "ophthalmology" and "global", etc. After the initial screening of these articles, repetitive literatures were excluded.

Results

69 articles were selected. This study introduces the ocular manifestations, possible pathogenesis, and treatment progress of Parry-Romberg syndrome.

Conclusion

There is currently no clear pathogenesis and effective treatment for Parry-Romberg syndrome. Understanding its pathological mechanism in the context of autoimmune etiology and exploring its phenotype-genotype correlation may help find more valuable treatments.