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Objectives <p>To evaluate the incidence of ocular ischemic syndrome (OIS) in patients with asymptomatic Severe Internal Carotid Artery Stenosis or occluded (ipICA-SO).</p> Design and methods <p>260 patients with ipICA stenosis ≥ 70%, 120 patients with ipsilateral OIS, and 140 with normal ocular condition. The logistic regression analysis was conducted to establish risk prediction models of OIS/Neovascular-OIS/Chronic-OIS for patients with ipICA-SO. The area under the receiver operating characteristic curve (AUC) was used to test the application value of the prediction models.</p> Results <p>In ipICA-SO patients, OIS patients showed significantly higher incidence of ipICA occlusion (<i>p</i> &lt; 0.001), plaque unstable (<i>p</i> &lt; 0.001 ipsilateral/contralateral) or plaque located at both the primary and siphon section (<i>p</i> = 0.004 in ipsilateral), contralateral ICA or anterior/middle cerebral artery severe stenosis (<i>p</i> = 0.001, 0.016, 0.040, respectively), and ipsilateral OphAr low /reflux blood flow (<i>p</i> &lt; 0.001). The hypertension was significantly higher in the control group (<i>p</i> = 0.002). The AUC of the prediction model of OIS was 0.834. Diabetes mellitus (DM) and OphAr reflux blood flow are risk factors for Neovascular-OIS. The AUC of Neovascular-OIS was 0.724. Chronic progress is likely in OIS patients with ipICA occlusion and DM. The AUC of Chronic-OIS was 0.673.</p> Conclusions <p>The ipICA-SO patients without sufficient collateral flow are more likely to develop OIS. IpICA-SO patients with hypertension had a lower risk of developing OIS. Neovascular was commonly found in OIS patients with DM and reversed OphAr blood flow. Chronic OIS was associated with ipICA total occlude and DM.</p>

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Incidence of ocular ischemic syndrome in patients with asymptomatic severe internal carotid artery stenosis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月3日

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  • Yanli Hou,
  • Simeng Tang,
  • Zhaoyang Meng,
  • Yingying Zhao,
  • Jing Li,
  • Hongyang Li,
  • Yanling Wang

摘要

Objectives

To evaluate the incidence of ocular ischemic syndrome (OIS) in patients with asymptomatic Severe Internal Carotid Artery Stenosis or occluded (ipICA-SO).

Design and methods

260 patients with ipICA stenosis ≥ 70%, 120 patients with ipsilateral OIS, and 140 with normal ocular condition. The logistic regression analysis was conducted to establish risk prediction models of OIS/Neovascular-OIS/Chronic-OIS for patients with ipICA-SO. The area under the receiver operating characteristic curve (AUC) was used to test the application value of the prediction models.

Results

In ipICA-SO patients, OIS patients showed significantly higher incidence of ipICA occlusion (p < 0.001), plaque unstable (p < 0.001 ipsilateral/contralateral) or plaque located at both the primary and siphon section (p = 0.004 in ipsilateral), contralateral ICA or anterior/middle cerebral artery severe stenosis (p = 0.001, 0.016, 0.040, respectively), and ipsilateral OphAr low /reflux blood flow (p < 0.001). The hypertension was significantly higher in the control group (p = 0.002). The AUC of the prediction model of OIS was 0.834. Diabetes mellitus (DM) and OphAr reflux blood flow are risk factors for Neovascular-OIS. The AUC of Neovascular-OIS was 0.724. Chronic progress is likely in OIS patients with ipICA occlusion and DM. The AUC of Chronic-OIS was 0.673.

Conclusions

The ipICA-SO patients without sufficient collateral flow are more likely to develop OIS. IpICA-SO patients with hypertension had a lower risk of developing OIS. Neovascular was commonly found in OIS patients with DM and reversed OphAr blood flow. Chronic OIS was associated with ipICA total occlude and DM.