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Purpose <p>To analyze levels of salivary steroids, including 17-OH-progesterone (17-OHP), androstenedione, dehydroepiandrosterone, cortisol, cortisone, progesterone, testosterone, and estradiol, in patients with acute central serous chorioretinopathy (CSCR) patients.</p> Methods <p>Acute CSCR patients and healthy individuals were included in this observational case–control study. Levels of salivary steroids were determined by high-performance liquid chromatography with tandem mass spectrometry detection. Clinical characteristics of CSCR patients were assessed based on multimodal imaging.</p> Results <p>Seventeen CSCR patients (40.1 ± 4.6&#xa0;years) and fourteen age-matched healthy controls (40.6 ± 3.8&#xa0;years) were included. Mean central retinal thickness and subfoveal choroidal thickness in affected eye of CSCR patients were 436.2 ± 131.1&#xa0;µm and 464.6 ± 132.6&#xa0;µm, respectively. Mean best-corrected visual acuity was 0.09 ± 0.11 LogMAR. Mean symptoms duration before saliva collection was 0.9 ± 0.6&#xa0;months. 17-OHP was decreased compared to the normal limits established in healthy controls in 10 out of 17 patients (59%), androstenedione in 15 out of 17 patients&#xa0;(88%), dehydroepiandrosterone in 10 out of 17 patients (59%), cortisol in 6 out of 17 patients&#xa0;(35%), cortisone in 12 out of 17 patients (83%), progesterone in 9 out of 17 patients&#xa0;(53%), testosterone in 10 out of 17 patients (59%), and estradiol in 5 out of 17 patients&#xa0;(29%). In total, among CSCR patients lower level in saliva was found for all studied hormones (<i>p</i> &lt; 0.05), except progesterone and estradiol.</p> Conclusion <p>Salivary steroids are decreased in acute CSCR male patients compared with age-matched controls. This may indicate inhibition of steroidogenesis caused by chronic stress and personal reactivity preceding manifestation of CSCR.</p>

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Salivary steroids in acute central serous chorioretinopathy

  • 期刊论文

  • 发表日期：

    2025年1月29日

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  • Dmitrii S. Maltsev,
  • Alexei N. Kulikov,
  • Alexander S. Vasiliev,
  • Jay Chhablani

摘要

Purpose

To analyze levels of salivary steroids, including 17-OH-progesterone (17-OHP), androstenedione, dehydroepiandrosterone, cortisol, cortisone, progesterone, testosterone, and estradiol, in patients with acute central serous chorioretinopathy (CSCR) patients.

Methods

Acute CSCR patients and healthy individuals were included in this observational case–control study. Levels of salivary steroids were determined by high-performance liquid chromatography with tandem mass spectrometry detection. Clinical characteristics of CSCR patients were assessed based on multimodal imaging.

Results

Seventeen CSCR patients (40.1 ± 4.6 years) and fourteen age-matched healthy controls (40.6 ± 3.8 years) were included. Mean central retinal thickness and subfoveal choroidal thickness in affected eye of CSCR patients were 436.2 ± 131.1 µm and 464.6 ± 132.6 µm, respectively. Mean best-corrected visual acuity was 0.09 ± 0.11 LogMAR. Mean symptoms duration before saliva collection was 0.9 ± 0.6 months. 17-OHP was decreased compared to the normal limits established in healthy controls in 10 out of 17 patients (59%), androstenedione in 15 out of 17 patients (88%), dehydroepiandrosterone in 10 out of 17 patients (59%), cortisol in 6 out of 17 patients (35%), cortisone in 12 out of 17 patients (83%), progesterone in 9 out of 17 patients (53%), testosterone in 10 out of 17 patients (59%), and estradiol in 5 out of 17 patients (29%). In total, among CSCR patients lower level in saliva was found for all studied hormones (p < 0.05), except progesterone and estradiol.

Conclusion

Salivary steroids are decreased in acute CSCR male patients compared with age-matched controls. This may indicate inhibition of steroidogenesis caused by chronic stress and personal reactivity preceding manifestation of CSCR.