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<p>Acute pancreatitis is an inflammatory condition characterized by an intense systemic inflammatory response and increased oxidative stress, which may compromise distant organs such as the lungs. In this context, natural compounds with antioxidant and anti-inflammatory properties have been investigated as potential therapeutic agents. Therefore, this study aimed to evaluate the effect of the fixed oil from <i>Syagrus coronata</i> in an experimental model of L-arginine-induced acute pancreatitis. Pancreatitis was induced in mice by two intraperitoneal injections of L-arginine (8%, 4&#xa0;g/kg). Animals were orally treated with <i>Syagrus coronata</i> fixed oil (ScFO) at doses of 25, 50, or 100&#xa0;mg/kg after disease induction. Serum biochemical parameters (amylase, lipase, and glucose), inflammatory cytokines (IL-1β, IL-6, and TNF-α), oxidative stress markers in lung tissue (MDA, SOD, and CAT), and histological alterations were evaluated. Pancreatitis induction significantly increased amylase, lipase, glucose, inflammatory cytokines, and lipid peroxidation, while reducing antioxidant enzyme activity in lung tissue. Treatment with ScFO at 50&#xa0;mg/kg reduced amylase (35.12%), lipase (40.74%), and glucose levels (20.24%), whereas the 100&#xa0;mg/kg dose produced reductions of 56.44%, 59.26%, and 30.95%, respectively. Decreases in IL-1β (32.05% and 52.56%), IL-6 (31.34% and 52.99%), and TNF-α (29.55% and 50%) were also observed at doses of 50 and 100&#xa0;mg/kg. In lung tissue, the oil reduced MDA levels by 34.78% and 54.71% and increased SOD and CAT activity at higher doses. The 25&#xa0;mg/kg dose showed no significant effect. These findings indicate that ScFO exerts a protective effect in experimental pancreatitis by reducing systemic inflammation and oxidative stress, particularly at doses of 50 and 100&#xa0;mg/kg.</p>

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Syagrus coronata fixed oil attenuates inflammation, oxidative stress and pulmonary alterations in L-arginine-induced pancreatitis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月24日

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  • Bruna de Sousa Gomes,
  • Beatriz Meyruze Barros da Fonsêca,
  • Laís Ruanita Leopoldina Galvão,
  • Beatriz Estandislau Lins de Carvalho,
  • Paulo Henrique Eloi Fernandes,
  • Edymilaís da Silva Sousa,
  • Anderson Arnaldo da Silva,
  • Júlio César Ribeiro dede Oliveira FariasAguiar,
  • Daniela Maria do Amaral Ferraz Navarro,
  • Alisson Macário de Oliveira,
  • Wêndeo Kennedy Costa,
  • Márcia Vanusa da Silva,
  • Maria Tereza dos Santos Correia

摘要

Acute pancreatitis is an inflammatory condition characterized by an intense systemic inflammatory response and increased oxidative stress, which may compromise distant organs such as the lungs. In this context, natural compounds with antioxidant and anti-inflammatory properties have been investigated as potential therapeutic agents. Therefore, this study aimed to evaluate the effect of the fixed oil from Syagrus coronata in an experimental model of L-arginine-induced acute pancreatitis. Pancreatitis was induced in mice by two intraperitoneal injections of L-arginine (8%, 4 g/kg). Animals were orally treated with Syagrus coronata fixed oil (ScFO) at doses of 25, 50, or 100 mg/kg after disease induction. Serum biochemical parameters (amylase, lipase, and glucose), inflammatory cytokines (IL-1β, IL-6, and TNF-α), oxidative stress markers in lung tissue (MDA, SOD, and CAT), and histological alterations were evaluated. Pancreatitis induction significantly increased amylase, lipase, glucose, inflammatory cytokines, and lipid peroxidation, while reducing antioxidant enzyme activity in lung tissue. Treatment with ScFO at 50 mg/kg reduced amylase (35.12%), lipase (40.74%), and glucose levels (20.24%), whereas the 100 mg/kg dose produced reductions of 56.44%, 59.26%, and 30.95%, respectively. Decreases in IL-1β (32.05% and 52.56%), IL-6 (31.34% and 52.99%), and TNF-α (29.55% and 50%) were also observed at doses of 50 and 100 mg/kg. In lung tissue, the oil reduced MDA levels by 34.78% and 54.71% and increased SOD and CAT activity at higher doses. The 25 mg/kg dose showed no significant effect. These findings indicate that ScFO exerts a protective effect in experimental pancreatitis by reducing systemic inflammation and oxidative stress, particularly at doses of 50 and 100 mg/kg.