Scholarlink

Background <p>Selenium and probiotics have been individually recognized for their antioxidant, anti-inflammatory, and immune-modulating properties. However, the potential synergistic effects of their co-supplementation in human health remain minimally investigated. This scoping review aimed to summarize the current evidence on the impact of co-supplementation with selenium and probiotics.</p> Methods <p>A comprehensive literature search was conducted across PubMed, Scopus, Embase, and Web of Science databases to identify clinical trials investigating the effects of selenium and probiotics co-supplementation. Eligible studies included randomized controlled trials (RCTs) and non-randomized clinical trials assessing clinical, metabolic, inflammatory, oxidative stress, and immune-related outcomes.</p> Results <p>Ten clinical studies met the inclusion criteria, including populations with polycystic ovary syndrome, Alzheimer’s disease, schizophrenia, leukemia, gestational diabetes, elderly nursing home residents, and ICU patients with stage I–II bedsores. Co-supplementation was associated with changes in glycemic indices (fasting plasma glucose, insulin, HOMA-IR, QUICKI), selected lipid parameters (triglycerides, total cholesterol, LDL cholesterol), oxidative stress markers (total antioxidant capacity, glutathione, malondialdehyde), and inflammatory markers, particularly high-sensitivity C-reactive protein. Studies also reported improvements in mental health scores, cognitive function (MMSE), and immune-related markers including adhesion molecules. Gene expression changes, including TNF-α and PPAR-γ, were reported in limited studies. Overall, co-supplementation was well tolerated, with no serious adverse events reported.</p> Conclusions <p>Selenium and probiotics co-supplementation may provide beneficial effects on metabolic regulation, oxidative stress, and inflammation-related conditions. However, heterogeneity in study design, probiotics’ strains, selenium dosage, and treatment duration limits firm conclusions. Larger, well-designed randomized controlled trials with long-term follow-up are needed.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Selenium and probiotics co-supplementation: A scoping review of clinical evidence

  • 期刊论文

  • 发表日期：

    2026年3月31日

查看全文
  • Amirhosein Dadashzadeh Asl,
  • Farnaz Naeimzadeh,
  • Reza Mostafaei Yonjali,
  • Aydin Mohammadpour,
  • Pouriya Golmohammadi Khankandi,
  • Ayda Afkhami,
  • Ata Mahmoodpoor,
  • Sarvin Sanaie,
  • Amirreza Naseri

摘要

Background

Selenium and probiotics have been individually recognized for their antioxidant, anti-inflammatory, and immune-modulating properties. However, the potential synergistic effects of their co-supplementation in human health remain minimally investigated. This scoping review aimed to summarize the current evidence on the impact of co-supplementation with selenium and probiotics.

Methods

A comprehensive literature search was conducted across PubMed, Scopus, Embase, and Web of Science databases to identify clinical trials investigating the effects of selenium and probiotics co-supplementation. Eligible studies included randomized controlled trials (RCTs) and non-randomized clinical trials assessing clinical, metabolic, inflammatory, oxidative stress, and immune-related outcomes.

Results

Ten clinical studies met the inclusion criteria, including populations with polycystic ovary syndrome, Alzheimer’s disease, schizophrenia, leukemia, gestational diabetes, elderly nursing home residents, and ICU patients with stage I–II bedsores. Co-supplementation was associated with changes in glycemic indices (fasting plasma glucose, insulin, HOMA-IR, QUICKI), selected lipid parameters (triglycerides, total cholesterol, LDL cholesterol), oxidative stress markers (total antioxidant capacity, glutathione, malondialdehyde), and inflammatory markers, particularly high-sensitivity C-reactive protein. Studies also reported improvements in mental health scores, cognitive function (MMSE), and immune-related markers including adhesion molecules. Gene expression changes, including TNF-α and PPAR-γ, were reported in limited studies. Overall, co-supplementation was well tolerated, with no serious adverse events reported.

Conclusions

Selenium and probiotics co-supplementation may provide beneficial effects on metabolic regulation, oxidative stress, and inflammation-related conditions. However, heterogeneity in study design, probiotics’ strains, selenium dosage, and treatment duration limits firm conclusions. Larger, well-designed randomized controlled trials with long-term follow-up are needed.