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<p>Inflammation is an important biological process, involving a cascade of molecular events in response to pathogenic triggers and plays a key role in the pathogenesis of many diseases. Trehalose, a natural disaccharide, exhibits strong anti-inflammatory properties. It has shown cytoprotective effects in multiple in vitro and in vivo models of inflammation-related disorders, including atherosclerosis, osteoarthritis, neurodegenerative diseases, and metabolic diseases. Trehalose mediates its anti-inflammatory effects by regulating key molecular pathways, including nuclear factor kappa B (NF-κB), mitogen-activated protein kinase (MAPK), and Janus kinase (JAK)-signal transducer and activator of transcription (STAT), as well as through regulation of oxidative stress, cellular homeostasis, and enhancement of autophagy. This review aims to summarize the underlying mechanisms by which trehalose influences the inflammatory response in various systems.</p> Graphical abstract <p>Overview of trehalose and its effects on different inflammatory diseases</p>

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Trehalose as an anti-inflammatory agent: insights into molecular mechanisms and therapeutic applications

  • 期刊论文

  • 发表日期：

    2026年3月10日

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  • Shabnam Radbakhsh,
  • Mohamed Benderdour,
  • Yasmine Maanani,
  • Julio C. Fernandes,
  • Amirhossein Sahebkar,
  • Hassan Fahmi

摘要

Inflammation is an important biological process, involving a cascade of molecular events in response to pathogenic triggers and plays a key role in the pathogenesis of many diseases. Trehalose, a natural disaccharide, exhibits strong anti-inflammatory properties. It has shown cytoprotective effects in multiple in vitro and in vivo models of inflammation-related disorders, including atherosclerosis, osteoarthritis, neurodegenerative diseases, and metabolic diseases. Trehalose mediates its anti-inflammatory effects by regulating key molecular pathways, including nuclear factor kappa B (NF-κB), mitogen-activated protein kinase (MAPK), and Janus kinase (JAK)-signal transducer and activator of transcription (STAT), as well as through regulation of oxidative stress, cellular homeostasis, and enhancement of autophagy. This review aims to summarize the underlying mechanisms by which trehalose influences the inflammatory response in various systems.

Graphical abstract

Overview of trehalose and its effects on different inflammatory diseases