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<p>Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation and pain, often leading to severe disability. Conventional treatments, including NSAIDs, DMARDs, and biologics, are expensive and associated with adverse effects, prompting interest in alternative therapies. Herbal synergy, which combines multiple medicinal plants, offers a promising holistic approach to RA management. This review explores the potential of herbal synergy in treating RA, focusing on the anti-inflammatory, immunomodulatory, and antioxidant properties of plants such as <i>Curcuma longa</i>, <i>Boswellia serrata</i>, <i>Withaniasomnifera</i>, <i>Zingiber officinale</i>etc. These herbs target various RA mechanisms, including inflammatory pathways and oxidative stress, while minimizing side effects. The review highlights these herbal combinations' mechanisms, efficacy, and safety and advocates for their integration into mainstream treatment regimens under expert supervision. The development of standardized formulations, rigorous clinical trials, and robust regulatory frameworks is essential to enhance their therapeutic potential.</p> Graphical abstract <p></p>

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Exploring herbal synergies in the management of rheumatoid arthritis: a multifaceted approach to inflammation and joint health

  • 期刊论文

  • 发表日期：

    2025年10月4日

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  • Shikhar Verma,
  • Mitali Panchpuri,
  • Vagish Dwibedi,
  • Santosh Kumar Rath,
  • Arti Devi

摘要

Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation and pain, often leading to severe disability. Conventional treatments, including NSAIDs, DMARDs, and biologics, are expensive and associated with adverse effects, prompting interest in alternative therapies. Herbal synergy, which combines multiple medicinal plants, offers a promising holistic approach to RA management. This review explores the potential of herbal synergy in treating RA, focusing on the anti-inflammatory, immunomodulatory, and antioxidant properties of plants such as Curcuma longa, Boswellia serrata, Withaniasomnifera, Zingiber officinaleetc. These herbs target various RA mechanisms, including inflammatory pathways and oxidative stress, while minimizing side effects. The review highlights these herbal combinations' mechanisms, efficacy, and safety and advocates for their integration into mainstream treatment regimens under expert supervision. The development of standardized formulations, rigorous clinical trials, and robust regulatory frameworks is essential to enhance their therapeutic potential.

Graphical abstract