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<p>Arthritis is a common joint-injury disease, and because its exact etiology and pathogenesis remain incompletely understood, current treatment options for it are highly limited. Conventional treatments focus on anti-inflammatory drugs to alleviate the disease. However, long-term use of these medications can cause increasingly serious side effects. Therefore, there is an urgent need to develop safe and effective anti-arthritis drugs with fewer side effects. Polysaccharides derived from natural products have received a lot of attention because of their safety and multiple active effects, wherein they have shown strong potential especially in the treatment of arthritis. However, a systematic presentation of polysaccharides against arthritis is still lacking. In this paper, we summarize the recent studies on natural polysaccharides for arthritis treatment mainly in terms of isolation, structure-anti-arthritic relationship, pharmacokinetics, mechanisms, and association of polysaccharides with other substances. It is helpful for researchers to fully understand the anti-arthritic effects of polysaccharides and provide some references for the development and application of polysaccharides in arthritis treatment.</p>

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Progress on the mechanism of natural polysaccharides in the treatment of arthritis

  • 期刊论文

  • 发表日期：

    2025年6月11日

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  • Lili Yuan,
  • Michael Adu-Frimpong,
  • Hong Chen,
  • Yaping Yang,
  • Jiangnan Yu,
  • Huiya Wang,
  • Yuxiang He,
  • Elmurat Toreniyazov,
  • Xia Cao,
  • Qilong Wang,
  • Ximing Xu

摘要

Arthritis is a common joint-injury disease, and because its exact etiology and pathogenesis remain incompletely understood, current treatment options for it are highly limited. Conventional treatments focus on anti-inflammatory drugs to alleviate the disease. However, long-term use of these medications can cause increasingly serious side effects. Therefore, there is an urgent need to develop safe and effective anti-arthritis drugs with fewer side effects. Polysaccharides derived from natural products have received a lot of attention because of their safety and multiple active effects, wherein they have shown strong potential especially in the treatment of arthritis. However, a systematic presentation of polysaccharides against arthritis is still lacking. In this paper, we summarize the recent studies on natural polysaccharides for arthritis treatment mainly in terms of isolation, structure-anti-arthritic relationship, pharmacokinetics, mechanisms, and association of polysaccharides with other substances. It is helpful for researchers to fully understand the anti-arthritic effects of polysaccharides and provide some references for the development and application of polysaccharides in arthritis treatment.