In this study, we have explored the structure and stability properties of anisotropic dark matter stars in four-dimensional Einstein-Gauss-Bonnet (4DEGB) theory. The model explores the joint role of the Gauss–Bonnet coupling ( \(\alpha \) ) and an anisotropy strength parameter ( \(\beta \) ) on global observables, integrating sequences to obtain mass-radius, mass-compactness, and mass-central density relations. Our numerical study uncovers two definitive trends: (i) for positive \(\alpha \) , the stars can be more massive with a larger radius, while \(\alpha <0\) favors more compact stars; across \(\alpha \in [-2,2]~\mathrm {km^2}\) , \(M_{\max }\) shifts from \(\sim 2.47\) to \(\sim 2.67\,M_\odot \) with radii near 13 km; and (ii) increasing \(\beta \) toward weaker anisotropy, i.e., from strongly negative values to \(\beta =0\) , leads to an increase in both mass and radius while lowering the central density at the turning point. We further checked the physical acceptability of all our solutions via the standard stability checks (segments with \(dM/d\rho _c>0\) , \(\gamma (r)>4/3\) , and \(0\le v_{r,\perp }^2\le 1\) ). These sequences adhere to the Buchdahl bound ( \(M/R<4/9\) ) and are compatible with observational bands associated with high-mass compact objects (GW190814, PSR J0952–0607, PSR J0348+0432). Overall, the findings indicate that dark-sector microphysics combined with higher-curvature corrections in 4DEGB gravity can support high-mass compact-star configurations in the \(\sim 2.5\) – \(2.7\,M_\odot \) range while satisfying the standard necessary conditions of physical acceptability.