We study Lie point symmetry structure of generalized nonlinear wave equations of the form \(\Box u=F(x, u, \nabla u)\) where \(\Box \) is the \((n+1)\) -dimensional space-time wave (or d’Alembert) operator, \(x\in \mathbb {R}^{n+1}\) ( \(n\ge 2\) ). We find the equivalence groups of this class and its subclass where the first order derivatives are absent. We then determine the symmetry group as a special case of the equivalence from the invariance requirement of the nonlinearity F leading to the symmetry condition involving F. As an application we solve this condition for some specific cases of F to build physically important equations like conformally-invariant nonlinear wave and Euler–Poisson–Darboux equation. Canonical forms for allowable symmetries are also studied.