<p>Non-pharmaceutical intervention (NPI) and prevailing health infrastructure play an inevitable part in the current scenario of pandemics in the world. However, in emerging economies, the infection burden of many health crises outstrips the resources available to treat all individuals. This study sought to provide preliminary empirical evidence on the contingency implications of resource allocation on personal protective equipment (PPE), health infrastructure and public health performance. A survey of 198 public health managers across Ghana was modelled via covariance-based structures using AMOS graphics version 23. The results show that the links between PPE, health infrastructure, quality health delivery and cost containment were statistically significant. In addition, resource allocation was found to moderate the relationships among PPE, health infrastructure, quality health delivery and cost containment. When decisions on resource allocation align with NPIs and prevailing health infrastructure, their associations with quality health delivery and cost containment strengthen in the Ghanaian context. Misalignment of resources with NPIs suggests that health managers have not yet fully adapted their resources to the NPIs being implemented. To enhance performance in a crisis, managers should ensure that the allocation of resources and health infrastructure are in a state of equilibrium with NPI implementation.</p>