<p>Trifluoromethylation reactions elicited a lot of attention because they are used to produce fluorinated compounds, which are extremely important in medicinal chemistry. The CF₃ group has exemplary properties such as high electron density, lipophilicity, enhanced acidity, and metabolic stability, and CF₃ substituted compounds play essential roles in medicines, agrochemicals, and materials research. This paper describes a successful electrochemical trifluoromethylation of Methyl Isonicotinate (MIN) using trifluoroacetic acid as the CF₃ donor and triethylamine, pyridine and sodium trifluoroacetate as redox mediators in an acetonitrile medium at platinum and glassy carbon electrodes using cyclic voltammetry. The approach is simple, eco-friendly, and pre-functionalization is not required. Linear sweep voltammetry indicates that MIN does not have a discrete oxidation peak of 0.016&#xa0;V vs. Ag, and the oxidation within the gas evolution region. TFA/NaTFA exhibits a little greater current density in the oxidation of MIN than in the other media. The adsorption of MIN/products on the glassy carbon electrode is indicated by broad anodic peaks in cyclic voltammetry. Galvanostatic electrolysis reveals that TFA/TEA/ACN gives superior conversion whereas TFA/NaTFA gives very low conversion (3%).</p> Graphical Abstract <p></p>