<p>Polymer composites have recently found numerous applications in biological fields like tissue engineering, dentistry, and implants. Certain polymer’s biocompatibility and non-toxic nature have enabled them to replace metallic materials in this field. Particularly polymer composite with glass fibre has been widely researched for this application. In this study, polypropylene and glass fibre composite are developed in the inhouse developed compression moulding setup. To achieve uniform characteristics of moulded composite this process uses hot mould that pertains to thermal consistency. This is achieved by placing equispaced cartridge heater. The moulding setup uses chopped E-glass fibre reinforced polypropylene composite at various process parameters. The prepared composite showed an rise in the tensile strength of polypropylene by 21% for 20 wt% of E-glass fibre. Further, E- glass fibre, polyoxymethylene and polypropylene based hybrid composite are developed to enhance the properties. Taguchi’s L₉ orthogonal array is used for design of experiments. The Signal to Noise Ratio analysis and ANOVA test is used to optimized parameters for maximising tensile strength and identify significant factors contribution, respectively. The results show that processing temperature and E-glass fibre wt% were the most influential parameters. The conformation study confirm the prediction accuracy of developed regression model with error of 3% from experimentally obtained tensile strength. Additionally, artificial neural model is developed, and prediction error is within 18% with experimental findings.</p>