Scholarlink

<p>In conventional gamma-ray imaging techniques in nuclear medicine, positron emission tomography based on coincidence detection of annihilation photons and single photon emission computed tomography using mechanical collimators are limited in spatial resolution to approximately 2-4 mm and 6-15 mm, respectively. In this study, we propose a novel gamma-ray imaging method based on measuring the angular correlation of cascade gamma rays with pulsed focused ultrasound application. When pulsed focused ultrasound with sufficient intensity to induce angular correlation changes is applied to a region containing <InlineEquation ID="IEq1"> <EquationSource Format="TEX">\(^{111}\)</EquationSource> </InlineEquation>In, one-dimensional positional information can be obtained from the time difference between the start of the pulse emission and the change in angular correlation. We demonstrated angular correlation changes induced by pulsed focused ultrasound and investigated the dependence of the change magnitude of the angular correlation when the start time of the analysis time window is shifted from -3 <InlineEquation ID="IEq2"> <EquationSource Format="TEX">\(\upmu \)</EquationSource> </InlineEquation>s to +3 <InlineEquation ID="IEq3"> <EquationSource Format="TEX">\({\upmu }\)</EquationSource> </InlineEquation>s in 1 <InlineEquation ID="IEq4"> <EquationSource Format="TEX">\({\upmu }\)</EquationSource> </InlineEquation>s intervals. The magnitude of the angular correlation change decreased as the analysis start time was shifted relative to the unshifted window. Because the shift time can be converted into distance using the ultrasound velocity in water, these results indicate the potential of pulsed focused ultrasound application and angular correlation measurements for source position discrimination.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Demonstration of a novel source localization method in nuclear medicine based on ultrasound-guided double-photon angular correlation

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月29日

查看全文
  • Mizuki Uenomachi,
  • Yoshiki Tamai,
  • Kenji Shimazoe,
  • Ayumu Ishijima

摘要

In conventional gamma-ray imaging techniques in nuclear medicine, positron emission tomography based on coincidence detection of annihilation photons and single photon emission computed tomography using mechanical collimators are limited in spatial resolution to approximately 2-4 mm and 6-15 mm, respectively. In this study, we propose a novel gamma-ray imaging method based on measuring the angular correlation of cascade gamma rays with pulsed focused ultrasound application. When pulsed focused ultrasound with sufficient intensity to induce angular correlation changes is applied to a region containing \(^{111}\) In, one-dimensional positional information can be obtained from the time difference between the start of the pulse emission and the change in angular correlation. We demonstrated angular correlation changes induced by pulsed focused ultrasound and investigated the dependence of the change magnitude of the angular correlation when the start time of the analysis time window is shifted from -3 \(\upmu \) s to +3 \({\upmu }\) s in 1 \({\upmu }\) s intervals. The magnitude of the angular correlation change decreased as the analysis start time was shifted relative to the unshifted window. Because the shift time can be converted into distance using the ultrasound velocity in water, these results indicate the potential of pulsed focused ultrasound application and angular correlation measurements for source position discrimination.