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<p>This study aims to evaluate the potential of metal–organic frameworks (MOFs) and MOF-hydrogel composites as advanced platforms for drug delivery systems (DDSs). The unique properties of MOFs, including their high porosity, tunable pore size, and functionalizability, are leveraged to address the limitations of conventional DDSs, such as their low stability, drug loading efficiency, and uncontrolled release. This review systematically examines the synthesis methodologies for MOFs and MOF-based hydrogels, including traditional, advanced, and alternative strategies. This paper further explores the mechanisms of drug encapsulation, drug-MOF interactions, and the role of hydrogel matrices in enhancing drug stability and release control. These findings highlight the ability of MOF-hydrogel systems to achieve pH-responsive, multidrug, and targeted delivery, with reduced burst release and improved therapeutic efficacy. Key applications in cancer therapy, antimicrobial treatments, and personalized medicine are discussed. In conclusion, MOF-hydrogel systems represent a promising strategy for precision medicine, although challenges such as biocompatibility and scalability remain areas for future research.</p>

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Exploring porous hybrid metal–organic framework hydrogel as a potential platform in drug delivery systems

  • 期刊论文

  • 发表日期：

    2025年3月12日

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  • Kamal Essifi,
  • Abdelqader El Guerraf,
  • Mohamed Brahmi,
  • Abdelouahab El Hadrami,
  • Rachid Brahmi,
  • Amine Moubarik,
  • Abdesselam Tahani

摘要

This study aims to evaluate the potential of metal–organic frameworks (MOFs) and MOF-hydrogel composites as advanced platforms for drug delivery systems (DDSs). The unique properties of MOFs, including their high porosity, tunable pore size, and functionalizability, are leveraged to address the limitations of conventional DDSs, such as their low stability, drug loading efficiency, and uncontrolled release. This review systematically examines the synthesis methodologies for MOFs and MOF-based hydrogels, including traditional, advanced, and alternative strategies. This paper further explores the mechanisms of drug encapsulation, drug-MOF interactions, and the role of hydrogel matrices in enhancing drug stability and release control. These findings highlight the ability of MOF-hydrogel systems to achieve pH-responsive, multidrug, and targeted delivery, with reduced burst release and improved therapeutic efficacy. Key applications in cancer therapy, antimicrobial treatments, and personalized medicine are discussed. In conclusion, MOF-hydrogel systems represent a promising strategy for precision medicine, although challenges such as biocompatibility and scalability remain areas for future research.