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<p>We used the rotifer <i>Brachionus dorcas</i>, a member of the <i>B. calyciflorus</i> species complex, to test the hypothesis that lifespan extension by rapamycin, a macrolide compound, is dose and developmental stage dependent. We also tested whether lifespan extension incurs fitness and/or body size costs. To this end, we studied the effects of juvenile, adult, and life-long rapamycin exposures on life expectancy, net reproductive rate, generation time, intrinsic rate of population increase, body size, and filtration and ingestion rates. To identify potential costs of lifespan extension, we analyzed the relationships between life expectancy and net reproductive rate, intrinsic rate of population increase, as well as body size. The results showed that compared with the control in the respective exposure regime, exposures to rapamycin at all tested concentrations do not significantly affect the life expectancy of rotifers in the juvenile exposure regime, but those to rapamycin at 0.5 and 2.0&#xa0;µM, and 0.5 and 1.0&#xa0;µM extend the life expectancy of rotifers in the adult and life-long exposure regimes, respectively. Life expectancy is negatively correlated with body size in the adult exposure regime, and net reproductive rate, intrinsic rate of population increase, and body size in the life-long exposure regime. These results indicated that the lifespan extension by rapamycin is dose and developmental stage dependent, and at the cost of reduced fitness and/or body size.</p>

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Lifespan extension by rapamycin in Brachionus dorcas (Rotifera) is dose and developmental stage dependent

  • 期刊论文

  • 发表日期：

    2025年1月23日

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  • Ting Liu,
  • Han-Bing Dong,
  • Bao-Chun Shi,
  • Hao-Yue Zhao,
  • Zhao-Yun Wang,
  • Lin Liu,
  • Wei-Lu Li,
  • Yi-Long Xi

摘要

We used the rotifer Brachionus dorcas, a member of the B. calyciflorus species complex, to test the hypothesis that lifespan extension by rapamycin, a macrolide compound, is dose and developmental stage dependent. We also tested whether lifespan extension incurs fitness and/or body size costs. To this end, we studied the effects of juvenile, adult, and life-long rapamycin exposures on life expectancy, net reproductive rate, generation time, intrinsic rate of population increase, body size, and filtration and ingestion rates. To identify potential costs of lifespan extension, we analyzed the relationships between life expectancy and net reproductive rate, intrinsic rate of population increase, as well as body size. The results showed that compared with the control in the respective exposure regime, exposures to rapamycin at all tested concentrations do not significantly affect the life expectancy of rotifers in the juvenile exposure regime, but those to rapamycin at 0.5 and 2.0 µM, and 0.5 and 1.0 µM extend the life expectancy of rotifers in the adult and life-long exposure regimes, respectively. Life expectancy is negatively correlated with body size in the adult exposure regime, and net reproductive rate, intrinsic rate of population increase, and body size in the life-long exposure regime. These results indicated that the lifespan extension by rapamycin is dose and developmental stage dependent, and at the cost of reduced fitness and/or body size.