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<p>Ulcerative colitis (UC) is a global inflammatory bowel disease (IBD) and is a chronic mucosal inflammation of the large intestine. UC is accompanied by the increment in the production and release of pro-inflammatory mediators. Due to the immunomodulatory potentials of Berberine (BBN), the present study aimed at examining its anti-ulcerogenic activity against experimentally induced ulcerative colitis (UC), by intrarectal instillation of 1&#xa0;ml of 3% acetic acid (AA). Thirty adults female Wistar rats were divided into three groups: (1) Negative control, (2) AA-induced UC rats (intrarectal), (3) Treated AA-induced UC + BBN (50&#xa0;mg/kg/day; orally). Biochemical, molecular, histopathological, and immunohistochemical investigations were conducted. Intrarectal administration of AA provoked several macroscopic and microscopic alterations in the colons of UC-induced rats, increased the colonic lipid peroxidation, upregulated the expression of nuclear factor kappa B (NF-κB), caspase-3, and interferon gamma (IFN-γ), increased levels of colonic inflammatory tumor necrosis factor-alpha (TNF-α), Interleukin-1 beta (IL-1β), and prostaglandin E 2 (PGE-2), and downregulated the immunoexpression of nuclear factor erythroid 2-related factor 2 (Nrf-2). In contrast, treatment of UC-rats with BBN exhibited curative activities manifested by downregulating the expression of NF-κB and caspase-3, reducing the colonic contents of malondialdehyde&#xa0;(MDA), TNF-α, IL-1β, and PGE-2; and activating Nrf-2 immunoexpression. This study evidenced the anti-ulcerative and colo-therapeutic potentials of BBN that might be ascribed to its anti-lipid peroxidation, anti-apoptotic, and anti-inflammatory activities.</p>

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The anti-ulcerative potential of Berberine on the rat model of inflammatory bowel disease

  • 期刊论文

  • 发表日期：

    2026年4月4日

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  • Ghadha Ibrahim Fouad,
  • Hanan F. Aly,
  • Dalia A. Taha,
  • Karima A. Hamed,
  • Ayda K. Kelany,
  • Wagdy K. B. Khalil,
  • Maha Z. Rizk

摘要

Ulcerative colitis (UC) is a global inflammatory bowel disease (IBD) and is a chronic mucosal inflammation of the large intestine. UC is accompanied by the increment in the production and release of pro-inflammatory mediators. Due to the immunomodulatory potentials of Berberine (BBN), the present study aimed at examining its anti-ulcerogenic activity against experimentally induced ulcerative colitis (UC), by intrarectal instillation of 1 ml of 3% acetic acid (AA). Thirty adults female Wistar rats were divided into three groups: (1) Negative control, (2) AA-induced UC rats (intrarectal), (3) Treated AA-induced UC + BBN (50 mg/kg/day; orally). Biochemical, molecular, histopathological, and immunohistochemical investigations were conducted. Intrarectal administration of AA provoked several macroscopic and microscopic alterations in the colons of UC-induced rats, increased the colonic lipid peroxidation, upregulated the expression of nuclear factor kappa B (NF-κB), caspase-3, and interferon gamma (IFN-γ), increased levels of colonic inflammatory tumor necrosis factor-alpha (TNF-α), Interleukin-1 beta (IL-1β), and prostaglandin E 2 (PGE-2), and downregulated the immunoexpression of nuclear factor erythroid 2-related factor 2 (Nrf-2). In contrast, treatment of UC-rats with BBN exhibited curative activities manifested by downregulating the expression of NF-κB and caspase-3, reducing the colonic contents of malondialdehyde (MDA), TNF-α, IL-1β, and PGE-2; and activating Nrf-2 immunoexpression. This study evidenced the anti-ulcerative and colo-therapeutic potentials of BBN that might be ascribed to its anti-lipid peroxidation, anti-apoptotic, and anti-inflammatory activities.